Human Genetic Cell Repository

The NIGMS Human Genetic Cell Repository, sponsored by the National Institute of General Medical Sciences, provides scientists around the world with resources for cell and genetic research. Established in 1972 at the Coriell Institute for Medical Research, the NIGMS Repository contains more than 11,800 cell lines, primarily fibroblasts and transformed lymphoblasts, and more than 5,900 DNA samples. Currently, the NIGMS HGCR catalog also contains over 85 iPSC lines.

Repository samples represent a variety of disease states, chromosomal abnormalities, apparently healthy individuals, and many distinct human populations. These samples comprise over 1,100 different OMIM diagnoses, and have been referenced in over 6,900 scientific publications.

Data on this website and information derived from the samples in the NIGMS Repository may not be used to determine the identity of any individual who provided a sample. Sample data available in the NIGMS Repository regarding race and/or ethnicity is self-reported information provided by sample submitters. Please direct any questions about these policies to


  • Dec 2021

    NIGMS Repository Address AMP Reference Materials Forum

    Co-PI of the NIGMS Repository, Matthew W. Mitchell, PhD, gave a presentation as part of the AMP Reference Materials Forum, which took place virtually earlier this month. This meeting focused on the research need and resource availability of genetic testing reference materials, such as DNA samples. Some of the more common research applications requiring the use of these well characterized biomaterials include: assay development, test validation, quality control, and proficiency testing.

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  • Nov 2021

    NIGMS Repository Staff Attends the RARE Health Equity Summit

    Team members from the NIGMS Repository traveled to Philadelphia this month to attend the RARE Health Equity Summit, sponsored by Global Genes. This inaugural meeting was developed to address inequities in the field of biomedical research informing health care in the rare disease community, particularly as they affect marginalized patient communities.

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  • Oct 2021

    High Molecular Weight DNA Now Available from NIGMS and NHGRI Collections

    The NIGMS Human Genetic Cell Repository (HGCR) and NHGRI Sample Repository for Human Genetic Research (SRHGR) now offer high molecular weight (HMW) DNA samples isolated from cell lines in the collections. HMW DNA is useful for long-read next-generation sequencing and studies that investigate large-scale genomic variation such as structural variation.

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