Postdoctoral researcher Tatanya Pozner's latest paper, Human iPSC Reprogramming Success: The Impact of Approaches and Source Materials, was published this January. The study provides a comparative analysis of leading non-integrating reprogramming methods across various starting source materials, evaluating their impact on reprogramming success rates, and was co-authored by NIGMS PI and Co-PI Drs. Nahid Turan and Matthew Mitchell. These findings hold valuable implications for biobanking, where the long-term reliability, integrity, and reproducibility of hiPSCs are essential.
The research underscores the importance of selecting appropriate reprogramming strategies tailored to specific cell types, shedding light on factors influencing efficiency, genomic stability, and differentiation potential. By addressing the challenges associated with variability in iPSC derivation, the study offers critical insights that could refine best practices in stem cell research and regenerative medicine. Furthermore, the findings may aid in enhancing the development of patient-derived disease models, supporting advancements in drug discovery and personalized medicine. Dr. Pozner’s work reinforces the growing need for standardized protocols to ensure reproducibility and reliability in biobanked iPSC lines, ultimately fostering greater collaboration and innovation in the field.
A link to the paper can be found here.
