iPSC Lines Added to NIST Reference Materials Collection


The Coriell Institute for Medical Research (Coriell) has added induced pluripotent stem cells (iPSC) to its collection of highly characterized cell lines offered by Coriell and the National Institute of Standards and Technology (NIST).

The iPSC lines were reprogrammed at Coriell from three cell lines (GM24385, GM24143, GM24631) from the Personal Genome Project collection. The original cell lines were released as NIST’s Reference Materials in the fall of 2016. These lines represent the mother and son of an Ashkenazic Jewish family trio and the son of a Han Chinese family trio.

This collection provides researchers with reliable, high quality cell cultures and DNA samples to be used as reference standards. The samples in this group have been widely sequenced and have been used to assess variant-call accuracy and better understand sequencing biases.

The addition of the iPSC lines offers researchers new flexibility in their work, providing the ability to differentiate into cells of different lineages and offering great potential for new medical applications.

"The collection of NIST Reference Materials has proven to be an important tool to ensure that researchers – from day one – are working with high quality and extensively characterized reference materials,” says Dr. Deborah Requesens, co-principal investigator of the NIGMS Human Genetic Cell Repository, which represents more than 1,000 unique human diseases, housed at Coriell. “Leveraging our stem cell expertise to generate iPSC lines for this collection is a natural extension of this partnership.”

To learn more about the collection or to order samples, click here.

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