Iberian populations in Spain [IBS]

The biomaterials currently available for this population are shown in the table below: 

Population  Iberian Populations in Spain [IBS]
DNA Sample Panel  MGP00010
Individual DNA Samples  157
Individual Cell Cultures  157

Principal Investigator

  • Alberto Orfao -Banco Nacional de ADN, University of Salamanca, Salamanca, Spain

Population Description

These cell lines and DNA samples were prepared from blood samples collected throughout the Spanish territory. In order to assure representativeness of all geographical areas, samples were collected from individuals who identified themselves as having been born in the area and having all four grandparents (two generations) born in the same area. The total number of geographical areas was 50, corresponding to the 50 administrative provinces (geographical areas surrounding a medium-large city) which constitute Spain, including the area in the Iberian Peninsula as well as the islands. All samples consist of mother-father-adult child trios. At least two trios were collected from each province, smaller entities than the 17 different autonomous regions of Spain. Thus, this set of samples can be viewed as generally representative of the population of Spain, with a broad geographic spread. The overall group contains some individuals from the Basque Country and from the Canary Islands, sometimes regarded as differentiated genetically.

The complete descriptor “Iberian Populations in Spain” should be used the first time these samples are referred to in an article or presentation. After the complete descriptor has been provided, it is acceptable to use the shorthand label“Iberian” or the abbreviation “IBS” in the remainder of the article or presentation. However, the full descriptor for the population should be provided before the shorthand labels are used; this will help to avoid the risks associated with over-generalization of findings.

It may be scientifically appropriate to pool data from these samples with data from other ancestrally related groups, when the data show that the groups have similar allele frequencies. If the groups are all have European ancestry, the designation “European ancestry” (EUA) to describe the combined analysis panel is recommended. If only groups very closely related to the Iberian populations in Spain have similar allele frequencies, then another abbreviation may be used.

Additional guidance about how to refer to the populations can be found at Guidelines for Referring to the Populations in Publications and Presentations.


Policies and Guidelines


References

1. Adams SM, et al. (2008) The genetic legacy of religious diversity and intolerance: paternal lineages of Christians, Jews, and Muslims in the Iberian Peninsula. Am J Hum Genet  83(6): 725-36.

2. Bauduer F, Feingold J, Lacombe D. (2005) The Basques: review of population genetics and Mendelian disorders. Hum Biol 77(5): 619-37.

3. Bertranpetit J, Cavalli-Sforza LL. (1991) A genetic reconstruction of the history of the population of the Iberian Peninsula.Ann Hum Genet 55: 51-67.

4. Bosch E, et al. (2001) High-resolution analysis of human Y-chromosome variation shows a sharp discontinuity and limited gene flow between northwestern Africa and the Iberian Peninsula. Am J Hum Genet 68(4): 1019-29.

5. Garagnani P, et al. (2009) Isolated populations as treasure troves in genetic epidemiology: the case of the Basques. Eur J Hum Genet 17(11): 1490-94.

6. Plaza S, et al. Joining the pillars of Hercules: mtDNA sequences show multidirectional gene flow in the western Mediterranean. (2003) Ann Hum Genet 67: 312-28.