Stem Cells at Coriell

Induced pluripotent stem cells (iPSC) offer hope to patients and promise to scientists due to their potential to elucidate disease pathology, cure diseases, reverse injuries and offer highly targeted therapies to improve health outcomes.

Coriell Institute establishes and banks high quality human iPSC lines and mouse embryonic stem cells (mESC).  Our team has developed core capabilities to maintain, characterize, bank, and distribute the highest quality iPSCs and mESCs. Our laboratories operate under the most stringent ISO 9001:2015 certified standard operating procedures, including performance of quality control testing and assessment of pluripotency. Each characterized iPS cell line is accompanied with a detailed Certificate of Analysis (CofA) upon completion.

Stem Cell Core Services

  • Reprogramming
  • Characterization
  • Differentiated cell lines
  • Expansion and banking
  • iPSC-derived organoids

Key iPSC Quality Control Assays

  • Post-thaw viability and growth rate
  • Sterility
  • Mycoplasma
  • Identity match (DNA fingerprinting)
  • G-banded karyotype
  • Affymetrix Genome-Wide Human SNP Array 6.0
  • Confirmation of integration-free reprogramming
  • Pluripotency
    • Alkaline phosphatase staining (AP Assay)
    • Immunocytochemistry (ICC) – cell surface markers
    • Flow cytometry – cell surface markers
    • hPSC Scorecard Assay
  • Tri-lineage differentiation potential

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The stem cells distributed by Coriell are strictly for research purposes and cannot be used in human subjects. For Repository iPSC lines, all terms described in the repository’s Material Transfer Agreement (Assurance Form) for the stem cell line must be agreed to prior to using stem cell lines from Coriell.

Investigators must be aware that iPSCs and mESCs require special media and handling. All stem cell lines are shipped frozen on dry ice. Investigators interested in obtaining these lines are encouraged to review the culture protocols and FAQs for freeze recovery, passaging, and cryopreservation information before placing their order. Customers who have technical questions can email stemcellbiobank@coriell.org for further information.

Please always refer to the individual cell line’s CofA for the specific cell line culture conditions. Detailed protocols are available on the appropriate repository page but should only be treated as general guidelines.