Brief Description
This panel contains 5 micrograms of DNA/well from 91 unique and unrelated White individuals from North America with generalized epilepsy. Of these, 39 are males and 52 females, with an age range at onset from 1-10 years. Two samples are duplicated as internal controls (ND01284, wells F02 and F06, and ND06663, wells H03 and H10), and three wells remain empty for additional laboratory controls.Phenotypic data collected on these subjects consisted of Epilepsy Clinical Data Elements as outlined in the Coriell NINDS Genetics Repository guidelines. For each of the samples present in this panel the cause of epilepsy is unknown, and it is not associated with another neurological condition (e.g. mental retardation or a birth defect).
All samples and data were collected with informed consent under local IRB approved protocols. These samples are generously shared by Drs. Russell Buono, Dr. Jeffrey Noebels, and Dr. Terry Scattergood.
Publications
Please cite the panel number and the NINDS Repository in any publications, and kindly share those references with the NINDS Repository Management Team at Coriell (NINDS@Coriell.org). Portions or all of this statement may be used in publications relevant to this panel.
Other Healthy Controls, Positive Controls
Control samples from individuals without neurological disease and with a range of clinical data are available via the NINDS Repository catalogue. Single samples from this panel can also be obtained, individually. Positive control samples for known causal genes are available, as listed, under specific disorders (see NINDS Repository catalog).