Description:
MAJOR AFFECTIVE DISORDER; OLD ORDER AMISH - 125480 OR 309200
Repository
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NIGMS Human Genetic Cell Repository
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Subcollection |
Old Order Amish Major Affective Disorder Heritable Diseases |
Class |
Disorders of the Nervous System |
Quantity |
25 µg |
Quantitation Method |
Please see our FAQ |
Biopsy Source
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Peripheral vein
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Cell Type
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B-Lymphocyte
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Tissue Type
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Blood
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Transformant
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Epstein-Barr Virus
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Sample Source
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DNA from LCL
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Race
|
White
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Ethnicity
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AMISH
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Family Member
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94
|
Confirmation
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Clinical summary/Case history
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Species
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Homo sapiens
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Common Name
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Human
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Remarks
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IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis |
|
Remarks |
Clinically affected; type I bipolar disorder (BPI); onset at age 13 with atypical bipolarity; severly pschotic; OCD traits and phobic symptoms; multiple episodes/hospitalizations; illness clearly BPI as followed 26 years after onset; daughter of GM11057 and GM11058 |
Ginns EI, Ott J, Egeland JA, Allen CR, Fann CS, Pauls DL, Weissenbachoff J, Carulli JP, Falls KM, Keith TP, Paul SM, A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish. Nat Genet12:431-5 1996 |
PubMed ID: 8630500 |
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