GM10335
LCL from B-Lymphocyte
Description:
MAJOR AFFECTIVE DISORDER; OLD ORDER AMISH - 125480 OR 309200
|
Repository
|
NIGMS Human Genetic Cell Repository
|
| Subcollection |
Old Order Amish Major Affective Disorder
Heritable Diseases |
| Class |
Disorders of the Nervous System |
|
Biopsy Source
|
Peripheral vein
|
|
Cell Type
|
B-Lymphocyte
|
|
Tissue Type
|
Blood
|
|
Transformant
|
Epstein-Barr Virus
|
|
Sample Source
|
LCL from B-Lymphocyte
|
|
Race
|
White
|
|
Ethnicity
|
AMISH
|
|
Family Member
|
54
|
|
Confirmation
|
Clinical summary/Case history
|
|
Species
|
Homo sapiens
|
|
Common Name
|
Human
|
|
Remarks
|
|
| IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis |
| |
| Remarks |
Clinically affected; type I bipolar disorder (BPI); onset at age 15; recurrent manic/hypomanic episodes over time; treated by family physician; sister of GM10343 |
| Ginns EI, Ott J, Egeland JA, Allen CR, Fann CS, Pauls DL, Weissenbachoff J, Carulli JP, Falls KM, Keith TP, Paul SM, A genome-wide search for chromosomal loci linked to bipolar affective disorder in the Old Order Amish. Nat Genet12:431-5 1996 |
| PubMed ID: 8630500 |
| |
| Pauls DL, Gerhard DS, Lacy LG, Hostetter AM, Allen CR, Bland SD, LaBuda MC, Egeland JA, Linkage of bipolar affective disorders to markers on chromosome 11p is excluded in a second lateral extension of Amish pedigree 110. Genomics11:730-6 1991 |
| PubMed ID: 1774072 |
| Split Ratio |
1:2 |
| Temperature |
37 C |
| Percent CO2 |
5% |
| Medium |
Roswell Park Memorial Institute Medium 1640 with 2mM L-glutamine or equivalent |
| Serum |
15% fetal bovine serum Not Inactivated |
| Substrate |
None specified |
| Subcultivation Method |
dilution - add fresh medium |
| Supplement |
- |
|