NIGMS Collection - Induced Pluripotent Stem Cells

Coriell Institute for Medical Research

Induced Pluripotent Stem Cells

To facilitate research on differentiated cell types and other biomedical investigations, the NIGMS Repository offers human induced pluripotent stem cell (hiPSC) lines derived from apparently healthy individuals or from individuals affected with heritable diseases. These hiPSCs were created using a variety of reprogramming techniques*.

Some of the available hiPSC lines were derived from externally submitted iPSC lines, where a distribution stock was made. Others were derived from established LCLs or Fibroblast lines available in the catalog. In addition to QC tests (viability, contamination, karyotyping, microarray genotyping, and microsatellite matches with the parent cell culture), extensive pluripotency characterizations are performed on each NIGMS Repository hiPSC line. Pluripotency characterizations include the following assays:

Surface antigen expression
Embryoid body formation
PluriTest gene expression assay

A complete Certificate of Analysis (CofA) that includes images and quantitative test results is available for each hiPSC line. The CofA PDF specifies which pluripotency characterizations were performed on each hiPSC line.

The Protocol PDFs outline the proper steps for successful handling of the hiPSCs. Additional information is also found on the CofA PDF, including necessary media components, substrates, passage methods, and split ratios.

* For commercial purposes, please note that Limited Use Label Licenses (LULLs) may apply.

Apparently Healthy hiPSC Lines

Records Return: (33)

Show

1

Catalog ID

Description

Parent Line

Transformant

Gender

Age

Race

Biopsy Source

Affected Status

Related Samples

Certificate of Analysis

Protocol

APPARENTLY HEALTHY FETAL TISSUE

Reprogrammed (Retroviral)

Male

20 FW

Black/African American

Lung

No

APPARENTLY HEALTHY FETAL TISSUE

Reprogrammed (Retroviral)

Female

16 FW

Black/African American

Skin

No

APPARENTLY HEALTHY FETAL TISSUE

Reprogrammed (Retroviral)

Female

16 FW

Black/African American

Lung

No

APPARENTLY HEALTHY FETAL TISSUE

Reprogrammed (Retroviral)

Male

20 FW

Black/African American

Skin

No

APPARENTLY HEALTHY FETAL TISSUE

Reprogrammed (Episomal)

Female

16 FW

Black/African American

Skin

No

APPARENTLY HEALTHY INDIVIDUAL

Not in Repository

Reprogrammed (Retroviral)

IP ACADEMIA JAPAN

Female

36 YR

White

Skin

No

APPARENTLY HEALTHY INDIVIDUAL

Reprogrammed (Lentiviral)

Female

20 YR

White

Skin

No

APPARENTLY HEALTHY INDIVIDUAL

Reprogrammed (Episomal)

Female

22 YR

White

Peripheral vein

No

APPARENTLY HEALTHY INDIVIDUAL

Reprogrammed (Episomal)

IP ACADEMIA JAPAN

Male

30 YR

Asian

Skin

No

APPARENTLY HEALTHY INDIVIDUAL

Reprogrammed (Retroviral)

IP ACADEMIA JAPAN

Male

62 YR

White

Skin

No

APPARENTLY HEALTHY INDIVIDUAL

Reprogrammed (Sendai)

Sendai-Cyto Tune

Female

67 YR

Black/African American

Skin

No

APPARENTLY HEALTHY INDIVIDUAL

Reprogrammed (Sendai)

Sendai-Cyto Tune

Male

23 YR

American Indian/Alaska Native

Skin

No

APPARENTLY HEALTHY INDIVIDUAL

Reprogrammed (Sendai)

Sendai-Cyto Tune

Female

16 YR

Other

Skin

No

APPARENTLY HEALTHY INDIVIDUAL

Reprogrammed (Sendai)

Sendai-Cyto Tune

Female

26 YR

Asian

Skin

No

PERSONAL GENOME PROJECT

Reprogrammed (Retroviral)

IP ACADEMIA JAPAN

Male

55 YR

White

Skin

No

PERSONAL GENOME PROJECT

Reprogrammed (Episomal)

IP ACADEMIA JAPAN

Female

74 YR

White

Unknown

PERSONAL GENOME PROJECT

Reprogrammed (Episomal)

IP ACADEMIA JAPAN

Male

45 YR

White

Unknown

PERSONAL GENOME PROJECT

Reprogrammed (Episomal)

IP ACADEMIA JAPAN

Male

33 YR

Asian

Unknown

PERSONAL GENOME PROJECT

Reprogrammed (Sendai)

Sendai-Cyto Tune

Male

45 YR

White

Unknown

PERSONAL GENOME PROJECT

Reprogrammed (Episomal)

IP ACADEMIA JAPAN

Male

64 YR

Chinese

Peripheral vein

Unknown

Disease-Specific hiPSC Lines

Records Return: (140)

Show>

1

Catalog ID

Diagnosis

Parent Line

Transformant

Gender

Age

Race

Biopsy Source

Affected Status

Gene(s)

Mutation(s)

Family and Associated Specimens

Certificate of Analysis

Protocol

ALAGILLE SYNDROME 1; ALGS1

Reprogrammed (Sendai)

Female

Sendai-Cyto Tune

17 YR

White

Skin

Yes

JAG1

C312X

ALZHEIMER DISEASE; AD

Reprogrammed (Retroviral)

Male

IP ACADEMIA JAPAN

83 YR

White

Skin

Yes

NQO1 NQO1

c.559C>T (p.P187S)
c.559C>T (p.P187S)

ALZHEIMER DISEASE; AD

Reprogrammed (Retroviral)

Female

IP ACADEMIA JAPAN

60 YR

Not Reported

Skin

Yes

APP

Duplication

ARGININOSUCCINIC ACIDURIA

Reprogrammed (Sendai)

Female

Sendai-Cyto Tune

36 YR

White

Blood

Yes

ARGININOSUCCINIC ACIDURIA

Reprogrammed (Sendai)

Female

Sendai-Cyto Tune

15 YR

White

Blood

Yes

ASL ASL ASL ASL

VAL178MET
VAL178MET
ARG193GLN
ARG193GLN

BEHCET SYNDROME

Reprogrammed (Sendai)

Female

Sendai-Cyto Tune

53 YR

White

Yes

BETHLEM MYOPATHY

Reprogrammed (Sendai)

Female

Sendai-Cyto Tune

18 YR

White

Blood

Yes

COL6A1

c.868G>T

BETHLEM MYOPATHY

Reprogrammed (Sendai)

Female

Sendai-Cyto Tune

41 YR

White

Blood

Yes

COL6A1

c.1003-1G>A

BETHLEM MYOPATHY

Reprogrammed (Sendai)

Female

Sendai-Cyto Tune

49 YR

White

Blood

Yes

COL6A1

c.841G>A

CANAVAN DISEASE

Reprogrammed (Sendai)

Female

Sendai-Cyto Tune

1 YR

Not Reported

Skin

Yes

ASPA ASPA ASPA

ALA305GLU
TYR231TER
GLY176ASP

CANCER OF THE BREAST, FAMILIAL; BCS

Reprogrammed (Sendai)

Female

Sendai-Cyto Tune

55 YR

White

Blood

Yes

CHEK2

c.190G>A (p.Glu64Lys)

CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 4; CMH4

Reprogrammed (Sendai)

Male

Sendai-Cyto Tune

29 YR

White

Blood

Yes

MYBPC3

c.1577_1580dupCACT (p.C528TfsX4)

CENTRAL CORE DISEASE OF MUSCLE

Reprogrammed (Sendai)

Female

Sendai-Cyto Tune

61 YR

Other

Blood

Yes

RYR1

ILE4898THR

CENTRONUCLEAR MYOPATHY - TYPE UNKNOWN

Reprogrammed (Sendai)

Male

Sendai-Cyto Tune

3 YR

Asian

Blood

Yes

CEREBRAL CREATINE DEFICIENCY SYNDROME 1; CCDS1

Reprogrammed (Sendai)

Male

Sendai-Cyto Tune

4 YR

Asian

Skin

Yes

SLC6A8

DEL EX10-11

CEREBRAL CREATINE DEFICIENCY SYNDROME 1; CCDS1

Reprogrammed (Sendai)

Male

Sendai-Cyto Tune

4 YR

White

Blood

Yes

SLC6A8

c.1222_1224DELTTC (p.F408del)

CEREBRAL CREATINE DEFICIENCY SYNDROME 2; CCDS2

Reprogrammed (Sendai)

Female

Sendai-Cyto Tune

18 YR

White

Blood

Yes

GAMT GAMT

c.299_c.311 dup13
c.233T>A

CEREBRAL CREATINE DEFICIENCY SYNDROME 2; CCDS2

Reprogrammed (Sendai)

Male

Sendai-Cyto Tune

3 YR

Asiatic Indian

Blood

Yes

GAMT

c.424_426delGAG (p.E142del)

CEREBRAL CREATINE DEFICIENCY SYNDROME 3; CCDS3

Reprogrammed (Sendai)

Female

Sendai-Cyto Tune

18 YR

Asian

Blood

Yes

GATM GATM

IVS3+1G>T (c.484+1G>T)
IVS3+1G>T (c.484+1G>T)

CEROID LIPOFUSCINOSIS, NEURONAL 2, LATE INFANTILE TYPE; CLN2

Reprogrammed (Episomal)

Female

IP ACADEMIA JAPAN

11 YR

Not Reported

Yes

CLN2 CLN2

IVS5AS, G>C, -1
IVS5-1G>A

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