Publications

DNA polymerase theta protects leukemia cells from metabolic-induced DNA damage
Vekariya U, Toma MM, Nieborowska-Skorska M, Le BV, Caron MC, Kukuyan AM, Sullivan-Reed K, Podszywalow-Bartnicka P, Chitrala KN, Atkins J, Drzewiecka M, Feng W, Chan J, Chatla S, Golovine K, Jelinek J, Sliwinski T, Ghosh J,
Matlawska-Wasowska K, Chandramouly G, Nejati R, Wasik MA, Sykes S, Piwocka K, Hadzijusufovic E, Valent P, Pomerantz RT, Morton G, Childers W, Zhao H, Paietta E, Levine RL, Tallman MS, Fernandez H, Litzow MR, Gupta G, Masson JY, Skorski T
Blood. 2022 Dec 29:blood.2022018428. doi: 10.1182/blood.2022018428. Epub ahead of print. PMID: 36580665.

Non-pathogenic microbiota accelerate age-related CpG Island methylation in colonic mucosa
Sun A, Park P, Cole L, Vaidya H, Maegawa S, Keith K, Calendo G, Madzo J, Jelinek J, Jobin C, Issa JJ.
Epigenetics. 2022 Dec 26:1-14. doi: 10.1080/15592294.2022.2160568. Epub ahead of print. PMID: 36572998.

Selective CDK9 Inhibition by Natural Compound Toyocamycin in Cancer Cells
O'Connell CL, Baer MR, Ørskov AD, Saini SK, Duong VH, Kropf P, Hansen JW, Tsao-Wei D, Jang HS, Emadi A, Holmberg-Thyden S, Cowland J, Brinker BT, Horwood K, Burgos R, Hostetter G, Youngblood BA, Hadrup SR, Issa JP, Jones P, Baylin SB, Pandey S, Djibo R, Darracq A, Calendo G, Zhang H, Henry RA, Andrews AJ, Baylin SB, Madzo J, Najmanovich R, Issa JJ, Raynal NJ.
Cancers (Basel). 2022 Jul 8;14(14):3340. doi: 10.3390/cancers14143340. PMID: 35884401; PMCID: PMC9324262.

Prospective comparison of outcomes with azacitidine and decitabine in patients with AML ineligible for
intensive chemotherapy 
Zeidan AM, Fenaux P, Gobbi M, Mayer J, Roboz GJ, Krauter J, Robak T, Kantarjian HM, Novák J, Jedrzejczak WW, Thomas X, Ojeda-Uribe M, Miyazaki Y, Min YH, Yeh SP, Brandwein JM, Gercheva L, Demeter J, Griffiths EA, Yee KWL, Issa JJ, Bewersdorf JP, Keer H, Hao Y, Azab M, Döhner H.
Blood. 2022 Jul 21;140(3):285-289. doi: 10.1182/blood.2022015832. PMID: 35507690; PMCID: PMC9305088.

Single cell transcriptomic analysis reveals cellular diversity of murine esophageal
epithelium
Kabir MF, Karami AL, Cruz-Acuña R, Klochkova A, Saxena R, Mu A, Murray MG, Cruz J, Fuller AD, Clevenger MH, Chitrala KN, Tan Y, Keith K, Madzo J, Huang H, Jelinek J, Karakasheva T, Hamilton KE, Muir AB, Tétreault MP, Whelan KA.
Nat Commun. 2022 Apr 20;13(1):2167. doi: 10.1038/s41467-022-29747-x. PMID: 35443762; PMCID: PMC9021266.

The Two-Hit Hypothesis Meets Epigenetics
Issa JP
Cancer Res. 2022 Apr 1;82(7):1167-1169. doi: 10.1158/0008-5472.CAN-22-0405. PMID: 35373289.

Genome-wide DNA methylation profile in feline haematological tumours: A preliminary study
Yamazaki J, Jelinek J, Yokoyama S, Takiguchi M.
Res Vet Sci. 2021 Nov;140:221-228. doi: 10.1016/j.rvsc.2021.09.002. Epub 2021 Sep 8. PMID: 34534903.

Obese status is associated with accelerated DNA methylation change in peripheral blood of senior dogs
Yamazaki J, Meagawa S, Jelinek J, Yokoyama S, Nagata N, Yuki M, Takiguchi M. 
Res Vet Sci. 2021 Oct;139:193-199. doi: 10.1016/j.rvsc.2021.07.024. Epub 2021 Jul 24. PMID: 34358922.

The Roles of DNA Demethylases in Triple-Negative Breast Cancer
Panjarian S, Issa JJ.
Pharmaceuticals (Basel). 2021 Jun 29;14(7):628. doi: 10.3390/ph14070628. PMID: 34209564; PMCID: PMC8308559.

Accelerated aging in normal breast tissue of women with breast cancer
Panjarian S, Madzo J, Keith K, Slater CM, Sapienza C, Jelinek J, Issa JJ.
Breast Cancer Res. 2021 May 22;23(1):58. doi: 10.1186/s13058-021-01434-7. PMID: 34022936; PMCID: PMC8140515.

DNA methylation landscape of 16 canine somatic tissues by methylation-sensitive restriction enzyme-based next
generation sequencing
Yamazaki J, Matsumoto Y, Jelinek J, Ishizaki T, Maeda S, Watanabe K, Ishihara G, Yamagishi J, Takiguchi M.
Sci Rep. 2021 May 11;11(1):10005. doi: 10.1038/s41598-021-89279-0. PMID: 33976289; PMCID: PMC8113467.

Genome-wide DNA methylation analysis of dogs with high lead exposure living near a lead mining area in Kabwe, Zambia
Yamazaki J, Toyomaki H, Nakayama SMM, Yabe J, Muzandu K, Jelinek J, Yokoyama S, Ikenaka Y, Takiguchi M, Ishizuka M.
Environ Pollut. 2021 Oct 1;286:117229. doi: 10.1016/j.envpol.2021.117229. Epub 2021 May 3. PMID: 33975213.

Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas
Hu X, Estecio MR, Chen R, Reuben A, Wang L, Fujimoto J, Carrot-Zhang J, McGranahan N, Ying L, Fukuoka J, Chow CW, Pham HHN, Godoy MCB, Carter BW, Behrens C, Zhang J, Antonoff MB, Sepesi B, Lu Y, Pass HI, Kadara H, Scheet P, Vaporciyan AA, Heymach JV, Wistuba II, Lee JJ, Futreal PA, Su D, Issa JJ, Zhang J.
Nat Commun. 2021 Jan 29;12(1):687. doi: 10.1038/s41467-021-20907-z. PMID: 33514726; PMCID: PMC7846738.

Cellular Heterogeneity-Adjusted cLonal Methylation (CHALM) improves prediction of gene expression
Xu J, Shi J, Cui X, Cui Y, Li JJ, Goel A, Chen X, Issa JP, Su J, Li W.
Nat Commun. 2021 Jan 15;12(1):400. doi: 10.1038/s41467-020-20492-7. PMID: 33452255; PMCID: PMC7811027.

Promoter methylation changes in ALOX12 and AIRE1: novel epigenetic markers for atherosclerosis
Kim JY, Choi BG, Jelinek J, Kim DH, Lee SH, Cho K, Rha SH, Lee YH, Jin HS, Choi DK, Kim GE, Kwon SU, Hwang J, Cha JK, Lee S, Issa JJ, Kim J.
Clin Epigenetics. 2020 May 12;12(1):66. doi: 10.1186/s13148-020-00846-0. PMID: 32398127; PMCID: PMC7218560.

Genome-wide DNA methylation analysis in canine gastrointestinal lymphoma
Ohta H, Yamazaki J, Jelinek J, Ishizaki T, Kagawa Y, Yokoyama N, Nagata N, Sasaki N, Takiguchi M.
J Vet Med Sci. 2020 May 20;82(5):632-638. doi: 10.1292/jvms.19-0547. Epub 2020 Mar 25. PMID: 32213750; PMCID: PMC7273592.

Genomic and epigenomic predictors of response to guadecitabine in relapsed/refractory acute myelogenous leukemia
Chung W, Kelly AD, Kropf P, Fung H, Jelinek J, Su XY, Roboz GJ, Kantarjian, HM, Azab M, Issa JJ.
Clin Epigenetics. 2019 Jul 22;11(1):106. doi: 10.1186/s13148-019-0704-3. PMID: 31331399; PMCID: PMC6647096.