Included below are two recent publications where researchers have used data from the 1000 Genomes Project to study Schizophrenia. Schizophrenia is a brain disease that affects how a person thinks and feels that can cause hallucinations, delusions and difficulties with behavior.
The first study looked at how genetic risk variants for schizophrenia behave in different types of brain cells. The authors describe the ways in which these variants may affect which genes are more or less active in brain cells. This understanding may also contribute to better treatments for schizophrenia.
For more information:
Biological underpinnings and genetic predisposition to schizophrenia within microrna-137 regulatory pathways across brain development
Translational Psychiatry, 2026 | https://doi.org/10.1038/s41398-026-03859-0
In the second study, researchers also studied how genes are regulated. The authors predicted the ways in which gene regulation changes over time and compared patterns in brain development and in adult brain cells. This work may help future studies focused on reducing environmental risks for schizophrenia.
For more information:
Schizophrenia risk variants modulate transcription factor binding and gene expression in cortical cell types
Cellular and Molecular Life Sciences, 2026 | https://doi.org/10.1007/s00018-026-06177-2
