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NG10644 DNA from LCL

Description:

ALZHEIMER DISEASE; AD

Affected:

Yes

Sex:

Female

Age:

55 YR (At Sampling)

  • Overview
  • Characterizations
  • Phenotypic Data
  • Publications
  • External Links

Overview

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Repository NIA Aging Cell Culture Repository
Subcollection Alzheimer's Disease
Quantity 10 µg
Quantitation Method Please see our FAQ
Biopsy Source Peripheral vein
Cell Type B-Lymphocyte
Tissue Type Blood
Transformant Epstein-Barr Virus
Sample Source DNA from LCL
Race Asian
Ethnicity JAPANESE
Family Member 2
Relation to Proband sister
Confirmation Clinical summary/Case history
ISCN 46,XX
Species Homo sapiens
Common Name Human
Remarks The Japanese donor is a clinically affected member of a family with Alzheimer's disease. She has a history of progressive dementia. Lymphoblast cultures from 3 affected sibs are AG10643, AG10645, and AG10646. The culture was initiated on 6/12/88 by transformation of lymphocytes with Epstein Barr virus. The cells grow in suspension and their morphology is spherical. The karyotype is 46,XX with 2% of the cells examined showing random chromosome gain. The legacy karyotype description shown in this Remark may not be representative of the current available product.

Characterizations

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IDENTIFICATION OF SPECIES OF ORIGIN Species of Origin Confirmed by Nucleoside Phosphorylase, Glucose-6-Phosphate Dehydrogenase, and Lactate Dehydrogenase Isoenzyme Electrophoresis and by Chromosome Analysis
 

Phenotypic Data

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Remarks The Japanese donor is a clinically affected member of a family with Alzheimer's disease. She has a history of progressive dementia. Lymphoblast cultures from 3 affected sibs are AG10643, AG10645, and AG10646. The culture was initiated on 6/12/88 by transformation of lymphocytes with Epstein Barr virus. The cells grow in suspension and their morphology is spherical. The karyotype is 46,XX with 2% of the cells examined showing random chromosome gain. The legacy karyotype description shown in this Remark may not be representative of the current available product.

Publications

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Schellenberg GD, Bird TD, Wijsman EM, Orr HT, Anderson L, Nemens E, White JA, Bonnycastle L, Weber JL, Alonso ME, et al, Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science258:668-71 1992
PubMed ID: 1411576
 
Schellenberg GD, Pericak-Vance MA, Wijsman EM, Moore DK, Gaskell PC Jr, Yamaoka LA, Bebout JL, Anderson L, Welsh KA, Clark CM, et al, Linkage analysis of familial Alzheimer disease, using chromosome 21 markers. Am J Hum Genet48:563-83 1991
PubMed ID: 1998342

External Links

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dbSNP dbSNP ID: 19031
NCBI GTR 104300 ALZHEIMER DISEASE; AD
OMIM 104300 ALZHEIMER DISEASE; AD
Omim Description ALZHEIMER DISEASE, FAMILIAL; FAD
  ALZHEIMER DISEASE; AD
  PRESENILE AND SENILE DEMENTIA
Pricing
Commercial:
$155.00USD
Academic &
Non-profit:
$72.00USD
NIA Grantees:
$62.00USD
Add to Cart
How to Order
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