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AG20627
LCL
from
B-Lymphocyte
Description:
NIA AGING CELL REPOSITORY'S LONGEVITY RESEARCH PROGRAM
Affected:
No
Sex:
Female
Age:
105
YR
(At Sampling)
Sample Description
Overview
Characterizations
Phenotypic Data
Publications
Culture Protocols
Overview
Repository
NIA Aging Cell Culture Repository
Subcollection
Apparently Healthy Collection
Biopsy Source
Peripheral vein
Cell Type
B-Lymphocyte
Tissue Type
Blood
Transformant
Epstein-Barr Virus
Sample Source
LCL from B-Lymphocyte
Race
White
Ethnicity
ENGLISH
Relation to Proband
proband
Confirmation
Clinical summary/Case history
ISCN
46,XX
Species
Homo
sapiens
Common Name
Human
Remarks
Donor reports breast cancer at age 72 with recurrance at age 95, anemia, osteoarthritis of the knee, hearing loss with aids in both ears, small stroke at age 103, cataracts removed from both eyes and was a smoker for 5 years; maternal grandfather lived to be 99 years of age
Characterizations
IDENTIFICATION OF SPECIES OF ORIGIN
Species of Origin confirmed by LINE assay
Phenotypic Data
Demographic Data
Relation to Proband
proband
Age at Sampling
105 YR
Sex
Female
Age of Onset(If not a control)
No Data
Age at Diagnosis(If not a control)
No Data
Hispanic or Latino/Not Hispanic or Latino
not yet reported
Racial Category
White
Country
No Data
Diagnosed By
No Data
Data Elements
Clinical Element Type: Longevity
(Baseline)
Heart Disease
High blood pressure
Yes
No
Unknown
Not applicable
Coronary artery disease
Yes
No
Unknown
Not applicable
Heart attack
Yes
No
Unknown
Not applicable
Valvular disease
Yes
No
Unknown
Not applicable
Atherosclerosis
Yes
No
Unknown
Not applicable
Other
No Data
Blood Disorders
Anemia
Yes
No
Unknown
Not applicable
Polycythemia
Yes
No
Unknown
Not applicable
Multiple myeloma
Yes
No
Unknown
Not applicable
Other
No Data
Lung Disease
Emphysema
Yes
No
Unknown
Not applicable
Asthma
Yes
No
Unknown
Not applicable
Shortness of breath
Yes
No
Unknown
Not applicable
Other
No Data
Gastrointestinal
Gastroesophageal reflux disease
Yes
No
Unknown
Not applicable
Gastritis
Yes
No
Unknown
Not applicable
Ulcers
Yes
No
Unknown
Not applicable
Polyps
Yes
No
Unknown
Not applicable
Other
No Data
Genitourinary
Benign prostate hypertrophy
Yes
No
Unknown
Not applicable
Cysts
Yes
No
Unknown
Not applicable
Hysterectomy
Yes
No
Unknown
Not applicable
Kidney/bladder stones
Yes
No
Unknown
Not applicable
Urinary frequency
Yes
No
Unknown
Not applicable
Other
No Data
Joint Diseases
Osteoarthritis
Yes
No
Unknown
Not applicable
Rheumatoid arthritis
Yes
No
Unknown
Not applicable
Osteoporosis
Yes
No
Unknown
Not applicable
Degenerative joint disease
Yes
No
Unknown
Not applicable
Other
No Data
Neurological & Psychiatric Disorders
Alzheimer disease
Yes
No
Unknown
Not applicable
Depression
Yes
No
Unknown
Not applicable
Anxiety
Yes
No
Unknown
Not applicable
Parkinson Disease
Yes
No
Unknown
Not applicable
Stroke
Yes
No
Unknown
Not applicable
Memory loss
Yes
No
Unknown
Not applicable
Hearing loss
Yes
No
Unknown
Not applicable
Insomnia
Yes
No
Unknown
Not applicable
Other
No Data
Eye Diseases
Cataracts
Yes
No
Unknown
Not applicable
Glaucoma
Yes
No
Unknown
Not applicable
Macular degeneration
Yes
No
Unknown
Not applicable
Other
No Data
General Health/Lifestyle
Diabetes
Yes
No
Unknown
Not applicable
If yes, then type:
Not applicable
Frailty
Yes
No
Unknown
Not applicable
High cholesterol
Yes
No
Unknown
Not applicable
Overweight
Yes
No
Unknown
Not applicable
Severe weight loss
Yes
No
Unknown
Not applicable
Smoker
Yes
No
Unknown
Not applicable
# of years as a smoker
5
Alcohol use
Yes
No
Unknown
Not applicable
Frequency of alcohol use
Less often
Cancer
Yes
No
Unknown
Not applicable
If yes, then type:
BREAST
Family History
Relative(s) over 90 years old
Yes
No
Unknown
Not applicable
Arthritis
Yes
No
Unknown
Not applicable
Diabetes
Yes
No
Unknown
Not applicable
Heart disease
Yes
No
Unknown
Not applicable
Hypertension
Yes
No
Unknown
Not applicable
High cholesterol
Yes
No
Unknown
Not applicable
Obesity
Yes
No
Unknown
Not applicable
Cancer
Yes
No
Unknown
Not applicable
If yes, then type:
No Data
Alzheimer disease
Yes
No
Unknown
Not applicable
Macular degeneration
Yes
No
Unknown
Not applicable
Other (including familial genetic disease)
No Data
Remarks
Donor reports breast cancer at age 72 with recurrance at age 95, anemia, osteoarthritis of the knee, hearing loss with aids in both ears, small stroke at age 103, cataracts removed from both eyes and was a smoker for 5 years; maternal grandfather lived to be 99 years of age
Publications
Bracci AN, Dallmann A, Ding Q, Hubisz MJ, Caballero M, Koren A
, The evolution of the human DNA replication timing program Proceedings of the National Academy of Sciences of the United States of America120:e2213896120 2023
PubMed ID:
36848554
Caballero M, Ge T, Rebelo AR, Seo S, Kim S, Brooks K, Zuccaro M, Kanagaraj R, Vershkov D, Kim D, Smogorzewska A, Smolka M, Benvenisty N, West SC, Egli D, Mace EM, Koren A
, Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation Human molecular genetics120:e2213896120 2021
PubMed ID:
35394024
Lee J, Bignone PA, Coles LS, Liu Y, Snyder E, Larocca D
, Induced pluripotency and spontaneous reversal of cellular aging in supercentenarian donor cells Biochemical and biophysical research communications120:e2213896120 2020
PubMed ID:
32115145
Culture Protocols
Split Ratio
1:3
Temperature
37 C
Percent CO2
5%
Medium
Roswell Park Memorial Institute Medium 1640 with 2mM L-glutamine or equivalent
Serum
15% fetal bovine serum Not Inactivated
Substrate
None specified
Subcultivation Method
dilution - add fresh medium
Supplement
-
Pricing
Commercial:
$257.00
USD
Academic &
Non-profit:
$103.00
USD
NIA Grantees:
$47.00
USD
Add to Cart
How to Order
Ordering Instructions
MTA / Assurance Form
Statement of Research Intent Form
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