Coriell Institute
Repository NIA Aging Cell Culture Repository
Subcollection Canadian Alzheimer Disease
Biopsy Source Arm
Cell Type Fibroblast
Tissue Type Skin
Transformant Untransformed
Race Caucasian
Ethnicity CANADIAN
Family Member 57
Relation to Proband VIII-50
Confirmation Clinical summary/Case history
Species Homo sapiens
Common Name Human
Remarks The donor, now deceased, was affected with Alzheimer's disease. Onset of the disease occured at age 45. This diagnosis was updated by the submitter on 3/2009. The skin biopsy was taken ante-mortem from the forearm. Culture was initiated on 8/17/84 using explants of minced skin. The cell morphology is fibroblast-like. Culture was frozen at PDL 5. A lymphoblast culture from same donor is AG07767.
PDL at Freeze 5.83
Passage Frozen 5
 
Remark The donor, now deceased, was affected with Alzheimer's disease. Onset of the disease occured at age 45. This diagnosis was updated by the submitter on 3/2009. The skin biopsy was taken ante-mortem from the forearm. Culture was initiated on 8/17/84 using explants of minced skin. The cell morphology is fibroblast-like. Culture was frozen at PDL 5. A lymphoblast culture from same donor is AG07767.
Sarasija S, Laboy JT, Ashkavand Z, Bonner J, Tang Y, Norman KR, Presenilin mutations deregulate mitochondrial Ca eLife7: 2017
PubMed ID: 29989545
 
Qiang L, Fujita R, Yamashita T, Angulo S, Rhinn H, Rhee D, Doege C, Chau L, Aubry L, Vanti WB, Moreno H, Abeliovich A, Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons Cell146:359-71 2010
PubMed ID: 21816272
 
McCoy KR, Mullins RD, Newcomb TG, Ng GM, Pavlinkova G, Polinsky RJ, Nee LE, Sisken JE, Serum- and bradykinin-induced calcium transients in familial Alzheimer's fibroblasts. Neurobiol Aging14:447-55 1993
PubMed ID: 8247227
 
St George-Hyslop PH, Tanzi RE, Polinsky RJ, Haines JL, Nee L, Watkins PC, Myers RH, Feldman RG, Pollen D, Drachman D, et al, The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science235:885-90 1987
PubMed ID: 2880399
 
Nee LE, Polinsky RJ, Eldridge R, Weingartner H, Smallberg S, Ebert M, A family with histologically confirmed Alzheimer's disease. Arch Neurol40:203-8 1983
PubMed ID: 6600923
No data is available
Cumulative PDL at Freeze 10.83
Passage Frozen 5
Split Ratio 1:4
Temperature 37 C
Percent CO2 5%
Percent O2 AMBIENT
Medium Eagle's Minimum Essential Medium with Earle's salts and non-essential amino acids
Serum 15% fetal bovine serum Not inactivated

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