NG07086
DNA from Mesothelial
Description:
OVARIAN CANCER
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Repository
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NIA Aging Cell Culture Repository
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| Subcollection |
Apparently Healthy Collection |
| Quantity |
10 µg |
| Quantitation Method |
Please see our FAQ |
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Biopsy Source
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Ascites fluid
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Cell Type
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Mesothelial
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Tissue Type
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Peritoneum
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Transformant
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Untransformed
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Sample Source
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DNA from Mesothelial
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Relation to Proband
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proband
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Confirmation
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Clinical summary/Case history
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Species
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Homo sapiens
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Common Name
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Human
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Remarks
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| PDL at Freeze |
4.84 |
| Passage Frozen |
6 |
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| IDENTIFICATION OF SPECIES OF ORIGIN |
Species of Origin Confirmed by Chromosome Analysis |
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| Remarks |
Normal human mesothelial cell strain LP-9. The culture was initiated on 10/1/83 by directly plating an ascites fluid cell suspension which had been stored frozen since removal from the peritoneal cavity of an ovarian cancer patient on 9/2/81. The culture medium must be supplemented with 10 nanograms/ml EGF and 0.4 micrograms/ml hydrocortisone. The cell morphology is fibroblast-like in medium supplemented with EGF, but is epithelial-like in medium without EGF. The karyotype is 46,XX; normal diploid female.***Must Ship Frozen*** The legacy karyotype description shown in this Remark may not be representative of the current available product. |
| Sekine S, Takase S, Hayase R, Noritsugu K, Maemoto Y, Ichikawa Y, Ogawa K, Kondoh Y, Osada H, Yoshida M, Ito A, Identification of a derivative of the alkaloid emetine as an inhibitor of the YAP-TEAD interaction and its potential as an anticancer agent Bioscience, biotechnology, and biochemistry87:501-510 2023 |
| PubMed ID: 36809780 |
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| Snell D, Gunde T, Warmuth S, Chatterjee B, Brock M, Hess C, Johansson M, Simonin A, Spiga FM, Weinert C, Kirk N, Bassler N, Campos Carrascosa L, Flückiger N, Heiz R, Wagen S, Giezendanner N, Alberti A, Yaman Y, Mahler D, Diem D, Lichtlen P, Urech D, An engineered T-cell engager with selectivity for high mesothelin-expressing cells and activity in the presence of soluble mesothelin Oncoimmunology12:2233401 2023 |
| PubMed ID: 37456982 |
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| Hyldbakk A, Fleten KG, Snipstad S, Åslund AKO, Davies CL, Flatmark K, Mørch Y, Intraperitoneal administration of cabazitaxel-loaded nanoparticles in peritoneal metastasis models Nanomedicine : nanotechnology, biology, and medicine48:102656 2022 |
| PubMed ID: 36646195 |
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| Micek HM, Rosenstock L, Ma Y, Hielsberg C, Montemorano L, Gari MK, Ponik SM, Kreeger PK, Model of collective detachment in high-grade serous ovarian cancer demonstrates that tumor spheroids produce ECM to support metastatic processes APL bioengineering7:016111 2022 |
| PubMed ID: 36875739 |
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| Rivera M, Toledo-Jacobo L, Romero E, Oprea TI, Moses ME, Hudson LG, Wandinger-Ness A, Grimes MM, Agent-based modeling predicts RAC1 is critical for ovarian cancer metastasis Molecular biology of the cell33:ar138 2022 |
| PubMed ID: 36200848 |
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| Hartono AB, Kang HJ, Shi L, Phipps W, Ungerleider N, Giardina A, Chen W, Spraggon L, Somwar R, Moroz K, Drewry DH, Burow ME, Flemington E, Ladanyi M, Lee SB, Salt-Inducible Kinase 1 is a potential therapeutic target in Desmoplastic Small Round Cell Tumor Oncogenesis11:18 2021 |
| PubMed ID: 35443736 |
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| Herbert SL, Fick A, Heydarian M, Metzger M, Wöckel A, Rudel T, Kozjak-Pavlovic V, Wulff C, Establishment of the SIS scaffold-based 3D model of human peritoneum for studying the dissemination of ovarian cancer Journal of tissue engineering13:20417314221088514 2021 |
| PubMed ID: 35340423 |
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| Sommerfeld L, Finkernagel F, Jansen JM, Wagner U, Nist A, Stiewe T, Müller-Brüsselbach S, Sokol AM, Graumann J, Reinartz S, Müller R, The multicellular signalling network of ovarian cancer metastases Clinical and translational medicine11:e633 2021 |
| PubMed ID: 34841720 |
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| Lin LL, Makwana S, Chen M, Wang CM, Gillette LH, Huang TH, Burney RO, Nicholson BJ, Kirma NB, Cellular junction and mesenchymal factors delineate an endometriosis-specific response of endometrial stromal cells to the mesothelium Molecular and cellular endocrinology539:111481 2020 |
| PubMed ID: 34624439 |
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| Smith RS, Odintsov I, Liu Z, Lui AJ, Hayashi T, Vojnic M, Suehara Y, Delasos L, Mattar MS, Hmeljak J, Ramirez HA, Shaw M, Bui G, Hartono AB, Gladstone E, Kunte S, Magnan H, Khodos I, De Stanchina E, La Quaglia MP, Yao J, Laé M, Lee SB, Spraggon L, Pratilas CA, Ladanyi M, Somwar R, Novel patient-derived models of desmoplastic small round cell tumor confirm a targetable dependency on ERBB signaling Disease models & mechanisms15:111481 2020 |
| PubMed ID: 34841430 |
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| Barbarino M, Cesari D, Bottaro M, Luzzi L, Namagerdi A, Bertolino FM, Bellan C, Proietti F, Somma P, Micheli M, de Santi MM, Guazzo R, Mutti L, Pirtoli L, Paladini P, Indovina P, Giordano A, PRMT5 silencing selectively affects MTAP-deleted mesothelioma: In vitro evidence of a novel promising approach Journal of cellular and molecular medicine15:111481 2019 |
| PubMed ID: 32301278 |
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| Bilandzic M, Rainczuk A, Green E, Fairweather N, Jobling TW, Plebanski M, Stephens AN, Keratin-14 (KRT14) Positive Leader Cells Mediate Mesothelial Clearance and Invasion by Ovarian Cancer Cells Cancers11:111481 2019 |
| PubMed ID: 31443478 |
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| Gormley CA, Keenan BJ, Buczek-Thomas JA, Pessoa ACSN, Xu J, Monti F, Tabeling P, Holt RG, Nagy JO, Wong JY, Fibrin-Targeted Polymerized Shell Microbubbles as Potential Theranostic Agents for Surgical Adhesions Langmuir : the ACS journal of surfaces and colloids11:111481 2019 |
| PubMed ID: 30681875 |
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| Zhang L, Singh A, Plaisier C, Pruett N, Ripley RT, Schrump DS, Hoang CD, Metadherin Is a Prognostic Apoptosis Modulator in Mesothelioma Induced via NF-?B-Mediated Signaling Translational oncology12:859-870 2019 |
| PubMed ID: 31054476 |
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| Cömertpay S, Gül Özçelik Demirbanka F, Lowered Cyclin E levels increase the efficiency and the specificity of capsaicin against cancerous cells of mesothelium Cellular and molecular biology (Noisy-le-Grand, France)66:98-104 2018 |
| PubMed ID: 33040793 |
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| Knudtson JF, McLaughlin JE, Santos MT, Binkley PA, Tekmal RR, Schenken RS, The Hyaluronic Acid System is Intact in Menstrual Endometrial Cells in Women With and Without Endometriosis Reproductive sciences (Thousand Oaks, Calif)66:1933719118766257 2018 |
| PubMed ID: 29621955 |
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| Jacobson BA, Thumma SC, Jay-Dixon J, Patel MR, Dubear Kroening K, Kratzke MG, Etchison RG, Konicek BW, Graff JR, Kratzke RA, Targeting eukaryotic translation in mesothelioma cells with an eIF4E-specific antisense oligonucleotide PLoS One8(11):e81669 2013 |
| PubMed ID: 24260583 |
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| Koo YH, Na YJ, Ahn MY, Jeon HN, Yeom JI, Lee KS, Expression of CD44 in endometrial stromal cells from women with and without endometriosis and its effect on the adherence to peritoneal mesothelial cells Obstet Gynecol Sci56(2):102-9 2013 |
| PubMed ID: 24327988 |
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| Kim M, Rooper L, Xie J, Kajdacsy-Balla AA, Barbolina MV., Fractalkine receptor CX(3)CR1 is expressed in epithelial ovarian carcinoma cells and required for motility and adhesion to peritoneal mesothelial cells. Mol Cancer Res10:11-24 2012 |
| PubMed ID: 22064656 |
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| Ren J, Xiao YJ, Singh LS, Zhao X, Zhao Z, Feng L, Rose TM, Prestwich GD, Xu Y, Lysophosphatidic acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration, and invasion of ovarian cancer cells Cancer research66:3006-14 2006 |
| PubMed ID: 16540649 |
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| Burleson KM, Boente MP, Pambuccian SE, Skubitz AP, Disaggregation and invasion of ovarian carcinoma ascites spheroids Journal of translational medicine [electronic resource]4:6 2005 |
| PubMed ID: 16433903 |
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| Burleson KM, Hansen LK, Skubitz AP, Ovarian carcinoma spheroids disaggregate on type I collagen and invade live human mesothelial cell monolayers Clinical & experimental metastasis21:685-97 2005 |
| PubMed ID: 16035613 |
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| Lucidi RS, Witz CA, Chrisco M, Binkley PA, Shain SA, Schenken RS, A novel in vitro model of the early endometriotic lesion demonstrates that attachment of endometrial cells to mesothelial cells is dependent on the source of endometrial cells. Fertil Steril84(1):16-21 2005 |
| PubMed ID: 16009148 |
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| Kanerva A, Bauerschmitz GJ, Yamamoto M, Lam JT, Alvarez RD, Siegal GP, Curiel DT, Hemminki A, A cyclooxygenase-2 promoter-based conditionally replicating adenovirus with enhanced infectivity for treatment of ovarian adenocarcinoma Gene therapy11:552-9 2004 |
| PubMed ID: 14999227 |
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| Casey RC, Oegema TR, Skubitz KM, Pambuccian SE, Grindle SM, Skubitz AP, Cell membrane glycosylation mediates the adhesion, migration, and invasion of ovarian carcinoma cells Clinical & experimental metastasis20:143-52 2003 |
| PubMed ID: 12705635 |
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| Kanerva A, Wang M, Bauerschmitz GJ, Lam JT, Desmond RA, Bhoola SM, Barnes MN, Alvarez RD, Siegal GP, Curiel DT, Hemminki A, Gene transfer to ovarian cancer versus normal tissues with fiber-modified adenoviruses. Mol Ther5(6):695-704 2002 |
| PubMed ID: 12027553 |
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| Casado E, Gomez-Navarro J, Yamamoto M, Adachi Y, Coolidge CJ, Arafat WO, Barker SD, Wang MH, Mahasreshti PJ, Hemminki A, Gonzalez-Baron M, Barnes MN, Pustilnik TB, Siegal GP, Alvarez RD, Curiel DT, Strategies to accomplish targeted expression of transgenes in ovarian cancer for molecular therapeutic applications. Clin Cancer Res7(8):2496-504 2001 |
| PubMed ID: 11489832 |
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| Lee TC, Zhang Y, Aston C, Hintz R, Jagirdar J, Perle MA, Burt M, Rom WN, Normal human mesothelial cells and mesothelioma cell lines express insulin-like growth factor I and associated molecules. Cancer Res53:2858-64 1993 |
| PubMed ID: 7684950 |
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| La Rocca PJ, Rheinwald JG, Anchorage-independent growth of normal human mesothelial cells: a sensitive bioassay for EGF which discloses the absence of this factor in fetal calf serum. In Vitro Cell Dev Biol21:67-72 1985 |
| PubMed ID: 3878841 |
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| LaRocca PJ, Rheinwald JG, Coexpression of simple epithelial keratins and vimentin by human mesothelium and mesothelioma in vivo and in culture. Cancer Res44:2991-9 1984 |
| PubMed ID: 6202404 |
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| Connell ND, Rheinwald JG, Regulation of the cytoskeleton in mesothelial cells: reversible loss of keratin and increase in vimentin during rapid growth in culture. Cell34:245-53 1983 |
| PubMed ID: 6192933 |
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