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ND03231 DNA from LCL

Description:

POPULATION/CONVENIENCE CONTROL
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL UPDATE OF PLATE NDPT008
NDPT079 NEUROLOGICALLY NORMAL CAUCASION CONTROL
NEUROLOGICALLY NORMAL CAUCASIAN CONTROL PANEL

Affected:

No

Sex:

Male

Age:

56 YR (At Sampling)

  • Overview
  • Phenotypic Data
  • Publications
  • External Links

Overview

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Repository NINDS Repository
Subcollection Control
Quantity 3 µg
Quantitation Method Please see our FAQ
Biopsy Source Peripheral vein
Cell Type B-Lymphocyte
Tissue Type Blood
Transformant Epstein-Barr Virus
Sample Source DNA from LCL
Race White
Ethnicity Not Hispanic/Latino
Country of Origin USA
Family History N
Species Homo sapiens
Common Name Human

Phenotypic Data

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Demographic Data
Relation to Proband No Data
Age at Sampling 56 YR
Sex Male
Age of Onset(If not a control) No Data
Age at Diagnosis(If not a control) No Data
Hispanic or Latino/Not Hispanic or Latino Not Hispanic/Latino
Racial Category White
Country USA
Diagnosed By No Data
 
Data Elements
Clinical Element Type: Control
  (Baseline)
Data collected by
This data was collected by  No Data
Longitudinal Data
Is this data Longitudinal (Follow-Up) Data? yes  no  
Type of Control
Type of Control  Population control
Medical History
Amyotrophic lateral sclerosis present  absent  
Ataxia present  absent  
Autism present  absent  
Bipolar (manic-depressive) present  absent  
Brain aneurysm present  absent  
Cancer present  absent  
Dementia Alzheimer's
Dementia
absent
Depression present  absent  
Diabetes present  absent  
Dystonia present  absent  
Epilepsy present  absent  
Heart disease present  absent  
Hypertension present   absent 
Memory loss present  absent  
Migraine present  absent  
Multiple sclerosis present  absent  
Muscle disease present  absent  
Obsessive Compulsive  No Data
Parkinson's present  absent  
Schizophrenia present  absent  
Stroke present  absent  
Suicide/Attempt present  absent  
Tourettes  No Data
Other present  absent  
Family History
Amyotrophic lateral sclerosis present  absent  
Ataxia present  absent  
Autism present  absent  
Bipolar (manic-depressive) present  absent  
Brain aneurysm present  absent  
Cancer present  absent  
Dementia Alzheimer's
Dementia
absent
Depression present  absent  
Diabetes present   absent 
Notes: SISTER, BROTHER
Dystonia present  absent  
Epilepsy present  absent  
Heart disease present  absent  
Hypertension present  absent  
memory loss present  absent  
Migraine present  absent  
Multiple sclerosis present  absent  
Muscle disease present  absent  
Obsessive Compulsive  No Data
Parkinson's present  absent  
Schizophrenia present  absent  
Stroke present  absent  
Suicide/Attempt present  absent  
Tourettes  No Data
Other present  absent  
Optional data
smoking history never  former smoker   current smoker 
years smoking  25 YEARS
Neurological examination yes  no  
State Examination (MMSE) score  No Data
Handedness  No Data

Publications

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Santoso JW, Do SK, Verma R, Do AV, Hendricks E, Ichida JK, McCain ML, Human iPSC-Derived Motor Neuron Innervation Enhances the Differentiation of Muscle Bundles Engineered with Benchtop Fabrication Techniques ACS biomaterials science & engineering11:1731-1740 2025
PubMed ID: 39973396
 
Berlind JE, Lai JD, Lie C, Vicente J, Lam K, Guo S, Chang J, Yu V, Ichida JK, KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids Neuron11:1731-1740 2024
PubMed ID: 40049159
 
Hendricks E, Quihuis AM, Hung ST, Chang J, Dorjsuren N, Der B, Staats KA, Shi Y, Sta Maria NS, Jacobs RE, Ichida JK, The C9ORF72 repeat expansion alters neurodevelopment Cell reports42:112983 2023
PubMed ID: 37590144
 
Lai JD, Berlind JE, Fricklas G, Lie C, Urenda JP, Lam K, Sta Maria N, Jacobs R, Yu V, Zhao Z, Ichida JK, KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury Cell stem cell31:519-536.e8 2023
PubMed ID: 38579683
 
Lee S, Jun YW, Linares GR, Butler B, Yuva-Adyemir Y, Moore J, Krishnan G, Ruiz-Juarez B, Santana M, Pons M, Silverman N, Weng Z, Ichida JK, Gao FB, Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD Neuron111:1381-1390.e6 2022
PubMed ID: 36931278
 
Linares GR, Li Y, Chang WH, Rubin-Sigler J, Mendonca S, Hong S, Eoh Y, Guo W, Huang YH, Chang J, Tu S, Dorjsuren N, Santana M, Hung ST, Yu J, Perez J, Chickering M, Cheng TY, Huang CC, Lee SJ, Deng HJ, Bach KT, Gray K, Subramanyam V, Rosenfeld J, Alworth SV, Goodarzi H, Ichida JK, SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS Cell stem cell30:171-187.e14 2021
PubMed ID: 36736291
 
Santoso JW, Li X, Gupta D, Suh GC, Hendricks E, Lin S, Perry S, Ichida JK, Dickman D, McCain ML, Engineering skeletal muscle tissues with advanced maturity improves synapse formation with human induced pluripotent stem cell-derived motor neurons APL bioengineering5:036101 2021
PubMed ID: 34286174
 
Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, Woolwine P, Huang M, Cowan MJ, Ge B, Koutsodendris N, Sandor KP, Komberg J, Vangoor VR, Senthilkumar K, Hennes V, Seah C, Nelson AR, Cheng TY, Lee SJ, August PR, Chen JA, Wisniewski N, Hanson-Smith V, Belgard TG, Zhang A, Coba M, Grunseich C, Ward ME, van den Berg LH, Pasterkamp RJ, Trotti D, Zlokovic BV, Ichida JK, Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons Nature medicine5:036101 2017
PubMed ID: 29400714
 
Edwards TL, Scott WK, Almonte C, Burt A, Powell EH, Beecham GW, Wang L, Züchner S, Konidari I, Wang G, Singer C, Nahab F, Scott B, Stajich JM, Pericak-Vance M, Haines J, Vance JM, Martin ER., Genome-Wide Association Study Confirms SNPs in SNCA and the MAPT Region as Common Risk Factors for Parkinson Disease Annals of Human Genetics74(2):97-109 2010
PubMed ID: 20070850
 
Matarín M, Brown WM, Scholz S, Simón-Sánchez J, Fung HC, Hernandez D, Gibbs JR, De Vrieze FW, Crews C, Britton A, Langefeld CD, Brott TG, Brown RD, Worrall BB, Frankel M, Silliman S, Case LD, Singleton A, Hardy JA, Rich SS, Meschia JF, A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release Lancet neurology6:414-20 2007
PubMed ID: 17434096
 
Schymick JC, Scholz SW, Fung HC, Britton A, Arepalli S, Gibbs JR, Lombardo F, Matarin M, Kasperaviciute D, Hernandez DG, Crews C, Bruijn L, Rothstein J, Mora G, Restagno G, Chiò A, Singleton A, Hardy J, Traynor BJ, Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data Lancet neurology6:322-8 2007
PubMed ID: 17362836
 
Fung HC, Scholz S, Matarin M, Simón-Sánchez J, Hernandez D, Britton A, Gibbs JR, Langefeld C, Stiegert ML, Schymick J, Okun MS, Mandel RJ, Fernandez HH, Foote KD, Rodríguez RL, Peckham E, De Vrieze FW, Gwinn-Hardy K, Hardy JA, Singleton A, Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data Lancet neurology5:911-6 2006
PubMed ID: 17052657
 
Li Y, Rowland C, Schrodi S, Laird W, Tacey K, Ross D, Leong D, Catanese J, Sninsky J, Grupe A, A case-control association study of the 12 single-nucleotide polymorphisms implicated in Parkinson disease by a recent genome scan American journal of human genetics78:1090-2; author reply 1092-4 2006
PubMed ID: 16685663

External Links

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dbGaP Link phs000089
  phs000101.v5.p1
  phs000102

Culture Protocols

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Split Ratio (Frequency) 1:3 (4 Days)
Temperature 37 C
Percent CO2 5%
Percent O2 AMBIENT
Medium Roswell Park Memorial Institute Medium 1640 with 2mM L-glutamine or equivalent
Serum 15% fetal bovine serum Not Inactivated
Substrate None specified
Subcultivation Method dilution - add fresh medium
Supplement -
Pricing
Commercial and Non-U.S.:
$0.00USD
U.S. Academic or
Non-profit:
$0.00USD
NINDS Repository Submitter (past or current) and/or Current NINDS Grantee
$0.00USD
Add to Cart
How to Order
  • Ordering Instructions
  • MTA / Assurance Form
  • Statement of Research Intent Form
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