| Demographic Data |
| Relation to Proband |
No Data |
| Age at Sampling |
58 YR |
| Sex |
Male |
| Age of Onset(If not a control) |
31 YR |
| Age at Diagnosis(If not a control) |
53 YR |
| Hispanic or Latino/Not Hispanic or Latino |
Not Hispanic/Latino |
| Racial Category |
White |
| Country |
USA |
| Diagnosed By |
No Data |
| |
| Data Elements |
| Clinical Element Type: Multiple System Atrophy |
| (Baseline) |
| Longitudinal Data |
| Is this data Longitudinal (Follow-Up) Data? |
yes no |
| Family History |
| Family history of Multiple System Atrophy |
present absent
Notes: FAMILY HISTORY OF MCLEOD SYNDROME, AFFECTED BROTHER, MOTHER IS CARRIER OF XK GENE MUTATION |
| Best Clinical Diagnosis |
| Progressive supranuclear palsy |
present absent |
| Diffuse Lewy Body disease |
present absent |
| Multiple system atrophy |
present absent |
| Gaze palsy |
present absent |
| Alzheimer's disease |
present absent |
| Corticobasal ganglionic degeneration |
present absent |
| Dementia |
present absent |
| Other (specify) |
present absent
Notes: MCLEOD SYNDROME, XK GENE MUTATION, CHOREA, SEIZURES, MILD COGNITIVE DECLINE, ELEVATED SERUM CREATINE PHOSPHOKINASE |
| Signs suggestive of MSA diagnosis |
| Orthostatic hypotension |
present absent |
| Urinary incontinence |
present absent |
| Incomplete bladder emptying |
present absent |
| Bradykinesia |
present absent |
| Rigidity |
present absent |
| Postural Instability |
present absent |
| Tremor |
present absent |
| Gait ataxia |
present absent |
| Ataxic dysarthria |
present absent |
| Limb ataxia |
present absent |
| Sustained gaze-evoked nystagmus |
present absent |
| Extensor plantar responses with hyperreflexia |
present absent |
| Features Suggestive of Another Diagnosis |
| Responsive to Levodopa |
present absent |
| Oculogyric crisis |
present absent |
| Neuroleptic treatment onset |
present absent |
| Hydrocephalus |
present absent |
| Delusions |
present absent |
| Early severe dementia |
present absent |
| Whipple's disease |
present absent |
| Focal sensory deficit |
present absent |
| History of hypoxia/anoxia |
present absent |
| History of alien limb syndrome |
present absent |
| History of repeated strokes |
present absent |
| History of encephalitis |
present absent |
| Brain tumor |
present absent |
| Prior history of repeated head injury |
present absent |
| Optional data |
| MSA Rating Scale Total Score |
No Data |