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ND32176 LCL from B-Lymphocyte

Description:

TOURETTE SYNDROME

Affected:

Yes

Sex:

Female

Age:

5 YR (At Sampling)

  • Overview
  • Phenotypic Data
  • External Links
  • Culture Protocols

Overview

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Repository NINDS Repository
Subcollection Tourette Syndrome
Biopsy Source Peripheral vein
Cell Type B-Lymphocyte
Tissue Type Blood
Transformant Epstein-Barr Virus
Sample Source LCL from B-Lymphocyte
Race White
Ethnicity Not Hispanic/Latino
Country of Origin USA
Family History N
Species Homo sapiens
Common Name Human

Phenotypic Data

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Demographic Data
Relation to Proband No Data
Age at Sampling 5 YR
Sex Female
Age of Onset(If not a control) 3 YR
Age at Diagnosis(If not a control) 4 YR
Hispanic or Latino/Not Hispanic or Latino Not Hispanic/Latino
Racial Category White
Country USA
Diagnosed By No Data
 
Data Elements
Clinical Element Type: Tourettes
  (Baseline)
Primary Lifetime Clinical Diagnosis
Tourette’s Disorder present   absent 
Chronic Multiple Tics present  absent  
Other Tic disorder present  absent  
Unaffected or undiagnosed primary blood relative of proband yes  no  
Symptoms: Motor Tics present   absent 
Symptoms: Vocal/Verbal Tics present   absent 
Age at Tic onset  3 YEARS OLD
Genetic Data of Subject
Mutation/s in subject's DNA (if present, describe) present  absent  unknown  
Secondary Lifetime Clinical Diagnosis
Obsessive compulsive disorder present  absent  
Notes: SYMPTOMS, ONSET AGE 3
Attention Deficit/Hyperactivity Disorder present  absent  
Notes: SYMPTOMS, ONSET AGE 3
Other (specify) present   absent 
Notes: ASPERGER'S DISORDER
Optional data
Handedness Right   Left  Ambidextrous 
smoking history never   former smoker  current smoker 
years smoking  No Data
Other family members
Other family members of this person in NINDS repository yes  no  
Family History of TS and related disorders in first degree relatives of subject
Tourette Syndrome or tic disorders present  absent  
Obsessive Compulsive Disorder (OCD) present  absent  
Notes: MATERNAL UNCLE
Attention Deficit Hyperactivity Disorder (ADHD) present  absent  
Notes: MATERNAL UNCLE
List all first degree relatives and diagnosis (TS, tic disorder, OCD, ADHD)  NONE (MATERNAL UNCLE (HAS OCD AND ADHD)
Family History of Neurological Disease in first degree relatives
Motor Neuron Disorders, including ALS present  absent  
Parkinson’s disease present  absent  
Epilepsy present  absent  
Cerebrovascular Disorders, including stroke and aneurysm present  absent  

External Links

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NCBI Gene Gene ID:2973
NCBI GTR 137580 GILLES DE LA TOURETTE SYNDROME; GTS
OMIM 137580 GILLES DE LA TOURETTE SYNDROME; GTS
Omim Description GILLES DE LA TOURETTE SYNDROME; GTS
  TOURETTE SYNDROMECHRONIC MOTOR TICS, INCLUDED

Culture Protocols

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Split Ratio (Frequency) 1:2 (4 Days)
Temperature 37 C
Percent CO2 5%
Percent O2 AMBIENT
Medium Roswell Park Memorial Institute Medium 1640 with 2mM L-glutamine or equivalent
Serum 15% fetal bovine serum Not Inactivated
Substrate None specified
Subcultivation Method dilution - add fresh medium
Supplement -
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