NDPT103
96 WELL PLATE OF DNA SAMPLES
Description:
ALS PANEL: WHITES FROM NORTH AMERICA, UPPER-LIMB ONSET
Aliquot Size:
5 µg each
Sex:
Males: 57 Females: 35
Brief Description:
This panel contains 5 micrograms of DNA from 92 unique and unrelated White individuals with sporadic amyotrophic lateral
sclerosis (ALS). These include 57 males and 35 females from North America. The age of ALS onset ranges from 40 years to 88 years. This was
defined as when symptom(s) of ALS were first noted (including at least one: lower motor neuron signs (LMN) including weakness, atrophy,
fasciculations; upper motor neuron (UMN) signs including spasticity, pathologic spread of reflexes, clonus, etc). Subjects represented on
NDPT103 met the El Escorial criteria for definite or probable, and were banked less than or equal to 6 years since ALS onset.
A more detailed description is also available. NDPT103 replaces NPDT029, and contains the same samples except: ND12936 (no longer available) and
ND10641 (no longer available) are removed and are replaced by ND10143 and ND09553. ND11897 and ND10000 each appear twice on the panel as
internal controls. Wells F07 and H04 are empty for addition of a laboratory control.
Plate Layout:
The specific position on the plates has been optimized to reduce any possible errors in
sample identity during the genotyping process.
| Abramzon Y, Johnson JO, Scholz SW, Taylor JP, Brunetti M, Calvo A, Mandrioli J, Benatar M, Mora G, Restagno G, Chiò A, Traynor BJ, Valosin-containing protein (VCP) mutations in sporadic amyotrophic lateral sclerosis Neurobiology of aging33:2231.e1-6 2012 |
| PubMed ID: 22572540 |
| |
| Lee T, Li YR, Chesi A, Hart MP, Ramos D, Jethava N, Hosangadi D, Epstein J, Hodges B, Bonini NM, Gitler AD, Evaluating the prevalence of polyglutamine repeat expansions in amyotrophic lateral sclerosis Neurology76:2062-5 2011 |
| PubMed ID: 21562248 |
|