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NDPT093 96 WELL PLATE OF DNA SAMPLES

Description: NEUROLOGICALLY NORMAL WHITE CONTROL PANEL

Aliquot Size: 5 µg each

Sex: Males: 48 Females: 44

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Brief Description: This panel contains 5 micrograms of DNA from 92 unique and unrelated White individuals from North America without neurological disorders. Of these, 48 are males and 44 are females, with age at collection ranging from 55-84 years. Data collected on these subjects consisted of Control Clinical Data Elements as outlined in the Coriell NINDS Genetics Repository guidelines. These data include a detailed medical and family history. None have a history of primary neurological illness. A more detailed description is also available. NDPT093 replaces NDPT006 and has the same samples except the following samples have been removed: ND01672, ND04404, ND03522, and ND03527. These have been replaced with: ND12982, ND12431, ND14384, and ND03654.
Plate Layout: The specific position on the plates has been optimized to reduce any possible errors in sample identity during the genotyping process.
Estrada K, Whelan CW, Zhao F, Bronson P, Handsaker RE, Sun C, Carulli JP, Harris T, Ransohoff RM, McCarroll SA, Day-Williams AG, Greenberg BM, MacArthur DG, A whole-genome sequence study identifies genetic risk factors for neuromyelitis optica Nature communications9:1929 2018
PubMed ID: 29769526
 
Li QS, Cheng P, Favis R, Wickenden A, Romano G, Wang H, SCN9A Variants may be Implicated in Neuropathic Pain Associated with Diabetic Peripheral Neuropathy and Pain Severity The Clinical journal of pain9:1929 2015
PubMed ID: 25585270
 
Raza MH, Domingues CE, Webster R, Sainz E, Paris E, Rahn R, Gutierrez J, Chow HM, Mundorff J, Kang CS, Riaz N, Basra MA, Khan S, Riazuddin S, Moretti-Ferreira D, Braun A, Drayna D, Mucolipidosis types II and III and non-syndromic stuttering are associated with different variants in the same genes European journal of human genetics : EJHG24:529-34 2015
PubMed ID: 26130485
 
Raza MH, Mattera R, Morell R, Sainz E, Rahn R, Gutierrez J, Paris E, Root J, Solomon B, Brewer C, Basra MA, Khan S, Riazuddin S, Braun A, Bonifacino JS, Drayna D, Association between Rare Variants in AP4E1, a Component of Intracellular Trafficking, and Persistent Stuttering American journal of human genetics97:715-25 2015
PubMed ID: 26544806
 
Vester A, Velez-Ruiz G, McLaughlin HM, NISC Comparative Sequencing Program HM, Lupski JR, Talbot K, Vance JM, Züchner S, Roda RH, Fischbeck KH, Biesecker LG, Nicholson G, Beg AA, Antonellis A, A loss-of-function variant in the human histidyl-tRNA synthetase (HARS) gene is neurotoxic in vivo Human mutation34:191-9 2012
PubMed ID: 22930593
 
Lee T, Li YR, Chesi A, Hart MP, Ramos D, Jethava N, Hosangadi D, Epstein J, Hodges B, Bonini NM, Gitler AD, Evaluating the prevalence of polyglutamine repeat expansions in amyotrophic lateral sclerosis Neurology76:2062-5 2011
PubMed ID: 21562248
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Catalog IDSexAge at SamplingFamilyRelationshipGeneMutationAffected
ND14384Male68 YRNINDS1483spouse  No
ND05500Male73 YRNINDS0540spouse  No
ND05071Female56 YRNINDS0529spouse  No
ND04343Male71 YRNINDS0524spouse  No
ND05093Male66 YRNINDS0520spouse  No
ND04853Female67 YRNINDS0502spouse  No
ND04771Male81 YRNINDS0495spouse  No
ND04675Female72 YRNINDS0493spouse  No
ND04637Female67 YRNINDS0492spouse  No
ND04575Male63 YRNINDS0484spouse  No
ND04568Male72 YRNINDS0483spouse  No
ND04498Female58 YRNINDS0479spouse  No
ND04291Male68 YRNINDS0457spouse  No
ND04214Female76 YRNINDS0456spouse  No
ND04152Female76 YRNINDS0451spouse  No
ND04302Male75 YRNINDS0433spouse  No
ND03885Male84 YRNINDS0430spouseLRRK2WILDTYPE for GLY2019 (Bi)No
ND03833Female65 YRNINDS0427spouseLRRK2WILDTYPE for GLY2019 (Bi)No
ND03704Female57 YRNINDS0408spouse  No
ND03587Female70 YRNINDS0385spouse  No
ND03463Male76 YRNINDS0377spouse  No
ND03102Male78 YRNINDS0349spouse  No
ND03096Female79 YRNINDS0348spouse  No
ND03047Female73 YRNINDS0342spouseLRRK2WILDTYPE for GLY2019 (Bi)No
ND02760Female60 YRNINDS0311spouseLRRK2WILDTYPE for GLY2019 (Bi)No
ND02751Female59 YRNINDS0309spouse  No
ND02690Female70 YRNINDS0288spouse  No
ND02633Female69 YRNINDS0277spouse  No
ND01491Female67 YRNINDS0174spouse  No
ND01570Female75 YRNINDS0165spouse  No
ND01323Female59 YRNINDS0132spouseLRRK2WILDTYPE for GLY2019 (Bi)No
ND00702Female62 YRNINDS0092spouse  No
ND00674Male80 YRNINDS0066spouse  No
ND03406Female83 YR    No
ND04431Female82 YR    No
ND04305Female80 YR    No
ND03660Female79 YR    No
ND03834Female74 YR    No
ND01493Female72 YR    No
ND01582Female72 YR    No
ND03710Female71 YR    No
ND03715Female70 YR    No
ND04788Female69 YR    No
ND05297Female69 YR    No
ND10951Female69 YR    No
ND03654Female68 YR    No
ND04992Female67 YR    No
ND05766Female65 YR    No
ND04361Female63 YR    No
ND04845Female63 YR    No
ND03510Female60 YR    No
ND04991Female60 YR    No
ND03971Female59 YR    No
ND05484Female57 YR    No
ND04484Female56 YR    No
ND04275Female55 YR    No
ND04532Female55 YR    No
ND12982 Male80 YR    No
ND04740Male79 YR    No
ND05029Male78 YR    No
ND03401Male76 YR    No
ND03711Male74 YR    No
ND03256Male72 YR    No
ND03227Male71 YR    No
ND04600Male71 YR    No
ND04502Male70 YR    No
ND05065Male70 YR    No
ND03665Male69 YR    No
ND05523Male69 YR    No
ND02652Male68 YR    No
ND04534Male68 YR    No
ND03110Male67 YR    No
ND05368Male66 YR    No
ND12431Male66 YR    No
ND05155Male65 YR    No
ND03938Male64 YR    No
ND04296Male64 YR    No
ND04350Male64 YR    No
ND03403Male62 YR    No
ND04536Male62 YR    No
ND05296Male61 YR    No
ND03261Male60 YR    No
ND03974Male59 YR    No
ND04274Male59 YR    No
ND03713Male58 YR    No
ND03770Male58 YR  LRRK2WILDTYPE for GLY2019 (Bi)No
ND05124Male58 YR    No
ND04639Male57 YR    No
ND05161Male57 YR    No
ND04900Male56 YR    No
ND05156Male56 YR    No
ND03633Male55 YR    No

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