Sameer Kalghatgi, PhD

Director, Laboratory Operations  

I am the Director of Laboratory Operations at the Coriell Institute. In this capacity, I manage all laboratory supervisors and staff by providing scientific and technical guidance and lead the laboratory teams in providing cell culture and molecular biology services for a large number of diverse customers and projects, including the
NIGMS Repository. My responsibilities include optimizing daily workflows to meet all deliverables by developing and streamlining laboratory processes, including SOPs, and troubleshooting, exploring and onboarding new technologies for the Molecular Biology, Cell Culture, Stem Cell and Cytogenetics Laboratories. The efficient and effective operations of these laboratories are critical to the success of the NIGMS Repository.

I work closely with the laboratory supervisors and the NIGMS PI and Co-PI to ensure that the laboratories are generating the highest quality products. Prior to joining Coriell, I was one of the founding employees and Senior Scientist at EP Technologies LLC, an
early stage company based in Akron, Ohio. I was a significant contributor to EPT’s extensive patent portfolio and was responsible for developing novel clinical applications of non-thermal plasma and driving major projects that proved the safety and feasibility of non-thermal plasma. As one of the founding employees, I led key plasma projects and served as the primary technical point of contact between EPT and external partners, pharma companies and regulatory agencies. I led EPT through POC, prototyping, pre-clinical animal studies to design lock, and clinical trials for commercializing plasma devices. I was also involved in product development activities for use of plasma as a sterilizing device. I was closely involved in identifying and inventing novel plasma applications, hiring and onboarding of staff, and driving two major projects that demonstrated the technical feasibility of topical drug delivery of large macromolecules and DNA plasmids using non-thermal plasma.

I completed my postdoctoral studies at Boston University, employing my expertise in systems biology, cell culture, biochemistry, molecular biology, gene expression analysis and animal studies to study the underlying action of long-term use of common antibiotics in increasing oxidative stress and mitochondrial dysfunction in mammalian cells. This work was published in Science Translational Medicine.

I received my undergraduate degree in electrical engineering from VJTI, University of Mumbai and earned my Doctor of Philosophy degree in Electrical and Computer Engineering from Drexel University in Philadelphia, PA. At Drexel University, my research involved the understanding of the mechanism of non-thermal plasma induced blood coagulation; developing various clinical applications of non-thermal atmospheric pressure dielectric barrier discharge plasma, and understanding the underlying molecular and biological mechanisms of interaction of non-thermal atmospheric pressure plasma with cells and living tissue.

Education

Postdoctoral Training - Boston University, Boston, MA, USA

PhD - Drexel University, Philadelphia, PA, USA

BE - Veermata Jijabai Technological Institute, Mumbai,
India

Publications

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