 Andres Kriete, Ph.D., Associate Professor for Bioinformation Engineering, is head of a joint Bioinformatics Initative between the Coriell Institute, Camden, NJ and Drexel University, Philadelphia, PA. At Drexel's School of Biomedical Engineering, Science and Health Systems (homepage) he is a core faculty at the Center of Integrated Bioinformatics. He is affiliated with the Drexel Institute of Basic and Applied Protein Science, the Greater Philadelphia Bioinformatics Alliance, and initiated an interdisciplinary systems biology working group.
At the Coriell Institute Andres Kriete directs the Biocomputing Laboratory. The role of the laboratory is to acquire, standardize, store, integrate and analyze a wide spectrum of digital biological data. This includes exhaustive image based phenotyping of cells (cytomics) and tissues as well as genomics based profiling methodologies. Integration of such data using novel systems biology approaches will support to a better understanding of complex interactions at the different levels of biological organization, specifically in aging research. Related experimental work focusses on fibroblast cell strains and the EGF/MAPK pathway.
Applications and developments encompass:
- longitudinal aging studies using cell cultures and tissues
- systems-oriented bioimaging and bioinformatics data analysis
- quantitative models of signaling and regulatory networks
- development of multiscale and spatio-temporal models
Andres Kriete earned a PhD in physics in 1986 from the University in Bremen (Germany), and worked as a computer scientist at Kontron Electronics Inc., Image Analysis Division, Munich, and as a research associate at the University of Wuerzburg. He was faculty member at the Medical School Giessen and Head of the Image Processing Laboratory at the Institute of Anatomy and Cell Biology from 1987 to 2000.
His expertise is in bioinformatics, bioimaging and systems biology. Andres Kriete developed a functional computer representation of lung and received his venia legendi (Habilitation) in 1997 at the Medical School at the University Clinic in Giessen. He received visiting Professor appointments at the University of Bremen, Institute of Complex Systems and Visualization (CeVis) and the University of Pittsburgh, Dept. of Bioengineering. In 2001 he joined TissueInformatics.Inc/ParadigmGenetics, Pittsburgh, as Director of Imaging Sciences and Bioinformatics. He was involved in R&D projects that included automated multidimensional imaging, image analysis, location proteomics, and correlative bioinformatics. Main applications were in diabetes drug target development and aging research.
Andres Kriete is founder and co-organizer of the international series of meetings under the title "Focus on Microscopy", being well recognized in the field of 3D microscopy and related technologies. He was Executive Director of the 2004 meeting in Philadelphia (http://www.focusonmicroscopy.org).
He is planning a workshop on the complexities of aging at the Santa Fe Institute in 2007.
Representative Publications
Kriete, A, Sokhansanj BA, Coppock DL, West GB.
Systems approaches to the networks of aging. Ageing Res Rev. 2006 Aug 10; PMID:16904954 abstract
Kriete, A
Biomarkers of Aging - Combinatorial or Systems Model? Jan 2006,
Science SAGE-KE
abstract
full text
Kriete A., Eils R. (2005) Computational Systems Biology. Academic Press-Elsevier.
Ghosh A., Miller D., Zou R., Pais H., Sokhansanj B., Kriete A. (2005)
Integrated spatio-temporal model of cell signaling.
FOSBE 2005, Santa Barbara (Conference Proceeding)
Weber R., Proctor J.M., Waldstein J.M., Kriete A. (2005)
CBR for modeling complex systems.
Int. Conference on Case Base Reasoning 2005, Chicago (Conference Proceeding)
Kriete, A., Papazoglou E., Edrissi B., Pais H., Pourrezaei K.
Automated quantification of quantum-dot-labelled epidermal growth factor receptor internalization via multiscale image segmentation.
J Microsc. 2006 Apr;222(Pt 1):22-7.
PMID: 1673471 abstract
Boyce K., Kriete, A, Nagatomi, S, Kelder B, Coschigano K , Kopchick J
Phenotypical Enrichment Strategies for Microarray Data Analysis Applied in a Type II Diabetes Study.
OMICS 9(3):251-65, 2005.
PMID: 16209639 abstract
Kriete A, Boyce K
Automated tissue analysis--a bioinformatics perspective.
Methods Inf Med 44:32-7, 2005.
PMID: 15778792 abstract
Kriete A, Anderson MK, Love B, Freund J, Caffrey JJ, Young MB, Sendera TJ, Magnuson SR, Braughler JM
Combined histomorphometric and gene-expression profiling applied to toxicology.
Genome Biol 4(5):R32. Epub 2003 Apr 30
PMID: 12734012 abstract
Young MB, DiSilvestro MR, Sendera TJ, Freund J, Kriete A, Magnuson SR
Analysis of gene expression in carbon tetrachloride-treated rat livers using a novel bioarray technology.
Pharmacogenomics J 3:41-52, 2003.
PMID: 12629582 abstract
Kriete, A.
Form and function of lung: analysis by scientific image computing.
Springer Series in Anatomy, Embryology and Cell Biology 145, 1998 (Monography)
PMID: 9854864 abstract
Kriete, A. (Editor):
Visualization in Biomedical Microscopies: 3-D imaging and computer applications.
VCH-Verlag, Weinheim, 1992
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