Coriell's Tissue and Specialized Cell (TSC) Laboratory establishes differentiated cell lines from human and animal tissue biopsies. Cells are subsequently characterized using specific antibodies in immunocytochemical assays.

In the last several years, the Tissue and Specialized Cell Laboratory has established cell cultures from neonatal foreskins to bank "trios" of fibroblast, melanocyte, and keratinocyte cell cultures in support of a National Institute of Aging program. These cultures are an important resource for scientists interested in these specific lineages. These cell lines are also valuable for establishing induced pluripotent stem (iPS) cells since they can be used to study differences in reprogramming efficiency and pluripotency based on the cell type.

The Coriell TSC laboratory has also developed expertise in differentiating and characterizing adipose stromal cells from human and mouse cells. More recently, TSC is supporting the Michael J. Fox Foundation's Parkinson's Progressive Marker Initiative project by banking and performing hemoglobin QC assays on biofluids such as serum and plasma that are critical biospecimens for scientists interested in Parkinson's disease research.

For more information, contact Michael D'Andrea, PhD.