The mission of the Coriell Institute Microarray Resource is to provide investigators with the tools they need to fulfill their research goals. Our services fall into two main categories. The first is sample preparation/data analysis for Affymetrix expression and SNP profiling GeneChips. The second is to assist in the design and analysis of arrays for non-model organism expression profiling or unique applications such as ChIP on chip or resequencing. For these experiments, the Resource, along with Affymetrix or other 3rd party vendor will work with investigators to produce an array, as well as, preparing samples for hybridization.

Herbert, A., M. E. Lenburg, D. Ulrich, N. P. Gerry, K. Schlauch, M. F. Christman. Open-access database of candidate associations from a genome-wide SNP scan of the Framingham Heart Study. Nature Genetics. 39:135-136.

Spira, A., J. Beane, V. Shah, K. Steiling, G. Liu, F. Schembri, S. Gilman, Y.-M. Dumas, P. Calner, P. Sebastiani, S. Sridhar, J. Beamis, C. Lamb, T. Anderson, N. Gerry, J. Keane, M. Lenburg, J. S. Brody. 2007. Airway Epithelial Gene Expression in the Diagnostic Evaluation of Smokers with Suspect Lung Cancer. Nature Medicine. 13:361-366.

Tchkonia, T, M. Lenburg, T. Thomou, N. Giorgadze, G. Frampton, T. Pirtskhalava, A. Cartwright, M. Cartwright, J. Flanagan, I. Karagiannides, N. Gerry, R. Forse, Y. Tchoukalova, M. Jensen, C. Pothoulakis, J. Kirkland. Identification of Depot-Specific Human Fat Cell Progenitors through Distinct Expression Profiles and Developmental Gene Patterns. American Journal of Physiology - Endocrinology and Metabolism. 292:298-307. 2007. preprint (1.0 MB, PDF)

Herbert, A., N. P. Gerry, M. McQueen, I. M. Heid, A. Pfeufer, T. Illig, H.-E. Wichmann, T. Meitinger, D. Hunter, F. B. Hu, G. Colditz, A. Hinney, J. Hebebrand, K. Koberwitz, X. Zhu, R. Cooper, K. Ardlie, H. Lyon, J. Hirschhorn, N. M. Laird, M. E. Lenburg, C. Lange and M. F. Christman. 2006. A common genetic variant is associated with adult and childhood obesity. Science. 5771:279-283. reprint (432 KB, PDF)

Klings, E. S., S. Safaya, A. H. Adewoye, A. Odhiambo, G. Frampton, M. Lenburg, N. Gerry, P. Sebastiani, M. H. Steinberg, and H. W. Farber. 2005. Differential Gene Expression in Pulmonary Artery Endothelial Cells Exposed to Sickle Cell Plasma. Physiological Genomics. 21:293-298.

King, C., N. Guo, G. M. Frampton, N. P. Gerry, M. E. Lenburg and C. L. Rosenberg. 2005. Reliability and reproducibility of gene expression measurements using amplified RNA from laser microdissected primary breast tissue with oligonucleotide arrays. Journal of Molecular Diagnostics. 7:57-64. reprint (429 KB, PDF)

Carson, J. P., N. Zhiang, G. Frampton, N. P. Gerry, M. E. Lenburg and M. F. Christman. 2004. Pharmacogenomic identification of targets for adjuvant therapy with the topoisomerase poison camptothecin. Cancer Research. 64:2096-104. reprint (251 KB, PDF)

Lenburg, M.E.; Liou, L. S.; Gerry, N. P.; Frampton, G. M.; Cohen, H. T.; Christman, M. F. Previously unidentified changes in renal cell carcinoma gene expression identified by parametric analysis of microarray data. BMC Cancer. 3:31. open access article

Gerry, N. P.; Witowski, N. E.; Day, J.; Hammer, R. P.; Barany, G.; Barany, F. Universal DNA Microarray Method for Multiplex Detection of Low Abundance Point Mutations. J. Mol. Bio., 1999, 292(2), 251-262.

Favis, R.; Day, J. P.; Gerry, N. P.; Phelan, C.; Narod, S.; Barany, F. Universal DNA array detection of small insertions and deletions in BRCA1 and BRCA2. Nature Biotechnology, 2000, 18, 561-564.

Witowski, N. E.; Leiendecker-Foster, C.; Gerry, N. P.; McGlennen, R. C.; Barany, G. Micro-array-based detection of select cardiovascular disease markers. BioTechniques, 2000, 29, 936-944.

Bergstrom, D. E.; Gerry, N. P. Precision Sequence-Specific Cleavage of a Nucleic Acid by a Minor Groove-Directed Metal Binding Ligand Linked Through N-2 of Deoxy-guanosine. J. Am. Chem. Soc., 1994, 116, 12067-12068.