Dr. Corriveau is the Principal Investigator for the Human Genetics Resource Center DNA and Cell Line Repository, a powerful and unique resource at the Coriell Institute that is sponsored by the National Institute of Neurological Disorders and Stroke (NINDS Repository). The mission of this project is to provide publicly available high quality biological samples that are linked to clinical data for high throughput human genetic discovery. These efforts are essential to develop improved intervention for many neurological disorders that are caused by multiple genes, or by a combination of environmental and genetic factors. The repository currently produces and distributes DNA and immortalized cell lines from thousands of individual patients of epilepsy, motor neuron disease, Parkinson’s disease, and stroke. The NINDS Genetic Resource Center was established in 2002. In the first four years of the Repository we collected samples from 13,719 individuals. Of these over 4,300 samples are publicly available, and hundreds more are added each month.
The bioinformatics component of the NINDS Human Genetic Resource Center is a publicly accessible web site that contains a catalog of the currently available biomaterials and their associated phenotypic data. Additionally, genotyping data are available for a large set of samples, and these data are also publicly available. The phenotypic and genotypic data are managed by a web-based system, which allows investigators to contribute to and use these resources with maximal efficiency.
Dr. Corriveau received his Ph.D. in 1994 from the University of California, San Diego, where he investigated the expression of neuronal nicotinic acetylcholine receptors in developing neurons and muscle. As a postdoctoral associate with Dr. Carla Shatz, he played a leadership role in the seminal discovery that class I major histocompatibility complex molecules are expressed in developing neurons, where they regulate synaptic development and plasticity. Dr. Corriveau's research program in recent years has demonstrated that the NMDA class of glutamate receptors plays a critical role in regulating naturally occurring cell death in the developing brain. This body of work, together with that of other investigators, suggests that neurological birth defects caused by NMDA receptor antagonists, such as alcohol and inhalants, may be due to amplified naturally occurring cell death in the developing brain.
Collaborations
As Principal Investigator of the NINDS Repository, Dr. Corriveau works closely with Dr. Margaret Keller, the co-Principal Investigator. In addition, he has ongoing collaborations with Dr. Andrei Belousov (Tulane University) and Dr. Giles Hardingham (University of Edinburgh). These collaborations continue Dr. Corriveau's studies investigating the role of NMDA receptors in mammalian brain development.
Publications - Original Observations in Refereed Journals
de Rivero Vaccari, J.C., Casey, G., Aleem, S., Park, W.-M., and Corriveau, R.A. (2006).
NMDA Receptors Protect Somatosensory Relay Neurons From Bax-Dependent Developmental Cell Death In Vivo.
PNAS 103(45):16971-6.
PMID: 17077143 abstract
Arumugam, H., Liu, X., Colombo, P.J., Corriveau, R.A., and Belousov, A.B. (2005).
NMDA Receptors Regulate Developmental Gap Junction Uncoupling Via CREB Signaling.
Nat. Neurosci. 8(12):1720-6.
PMID: 16299502 abstract
Sugiura, N., Dadashev, V., and Corriveau, R.A. (2004).
NMDA receptor-regulated gene 2 encodes a novel nuclear protein that is expressed during development.
Eur. J. Biochem. 271(23-24):4629-4637.
PMID: 15606750 abstract
Adams, S.M., de Rivero Vaccari, J.C., and Corriveau, R.A. (2004).
Pronounced Cell Death in the Absence of NMDA Receptors in the Developing Somatosensory Thalamus.
J. Neurosci. 24(42):9441-9450.
PMID: 15496680 abstract
Sugiura, N., Adams, S.M., and Corriveau, R.A. (2003).
An Evolutionarily Conserved N-terminal Acetyltransferase Associated with Neuronal Development. J. Biol. Chem. 278(41):40113-40120.
PMID: 12888564 abstract
Sugiura, N., Patel, R.G., and Corriveau, R.A. (2001).
NMDA Receptors Regulate a Group of Transiently Expressed Genes in the Developing Brain.
J. Biol. Chem. 276(17):14257-14263.
PMID: 11297529 abstract
Corriveau, R.A., Shatz, C.J., and Nedivi, E. (1999).
Dynamic Regulation of cpg15 During Activity-Dependent Synaptic Development in the Mammalian Visual System.
J. Neurosci. 19(18):7999-8008.
PMID: 10479700 abstract
Corriveau, R.A., Huh, G.S., and Shatz, C.J. (1998).
Regulation of Class I MHC Gene Expression in the Developing and Mature CNS by Neural Activity.
Neuron 21:505-520.
PMID: 9768838 abstract
Romano, S.J., Corriveau, R.A., Schwarz, R.I., and Berg, D.K. (1997).
Expression of the Nicotinic Receptor a7 Gene in Tendon and Periosteum During Early Development.
Neurochem. 68(2):640-648.
PMID: 9003051 abstract
Corriveau, R.A., Romano, S.J., Conroy, W.G., Oliva, L., and Berg, D.K. (1995)
Expression of Neuronal Acetylcholine Receptor Genes in Vertebrate Skeletal Muscle During Development.
J. Neurosci. 15(2):1372-1383.
PMID: 7869104 abstract
Pugh, P.C., Corriveau, R.A., Conroy, W.G., and Berg, D.K. (1995).
A Subpopulation of Neuronal Acetylcholine Receptors Among Those Binding a-Bungarotoxin.
Molecular Pharmacology 47:717-725.
PMID: 7723732 abstract
Corriveau, R.A., and Berg, D.K. (1994).
Neurons in Culture Maintain Acetylcholine Receptor Levels with Far Fewer Transcripts than In Vivo.
J. Neurobiology 25 (12):1579-1592.
PMID: 7861121 abstract
Corriveau, R.A., and Berg, D.K. (1993).
Coexpression of Multiple Acetylcholine Receptor Genes in Neurons: Quantification of Transcripts During Development.
J. Neurosci. 13:2662-2671.
PMID: 8501530 abstract
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