 Lorraine H. Toji, Ph.D. is Associate Professor and Director of the Nucleic Acids Group where she oversees the isolation and molecular characterization of DNA samples in the Coriell Cell Repositories.
Dr. Toji's laboratory supplies the scientific community with the very highest quality DNA for research on understanding the human genome. In cooperation with the Institute's Molecular Biology Group this laboratory is responsible for quality control studies confirming the identities of cell cultures and DNA:
- including molecular characterization of somatic cell hybrids by PCR with markers specifically mapped to particular portions of individual chromosomes
- confirmation of identity of samples and family relationships by genotyping with fluorescently tagged primers for 6 microsatellite loci.
During the past ten years, the Coriell Institute has distributed nearly 250,000 DNA samples worldwide and currently stores over 900,000 samples of DNA. By supplying high quality biomaterials to the leaders in the field of human genetics, Coriell truly facilitates edge research.
Trained as a nucleic acids biochemist, Dr. Toji completed a master's degree at Wayne State University. After teaching college chemistry for three years, she returned to graduate school at Stanford University, and then transferred to and completed her Ph.D. at the Graduate School of Arts and Sciences at the University of Pennsylvania Medical School.
Representative Publications
Leonard, JC, Toji, LH, Bender PK, Beiswanger, CM, Beck, JC, Johnson, RT
Regional Mapping Panels for Human Chromosomes 1, 2, and 7.
Somatic Cell and Molecular Genetics 25(4):247-251, 2001.
Masters, JR, Thomson, JA, Daly-Burns, B, Reid, YA, Dirks, WG, Packer, P, Toji, LH, Ohno, T, Tanabe, H, Arlett, CF, Kelland, LR, Harrison, M, Virmani, A, Ward, TH, Ayres, KL, Debenham, PG
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proceedings of the National Academy of Sciences 98(14):8012-7, 2001.
PMID: 11416159 abstract
full text
Leonard JC, Toji LH, Bender PK, Beiswanger CM, Beck JC, Johnson RT
Panel description. Regional mapping panels for chromosomes 6, 9, and 16.
Genomics 58(3):323-6, 1999.
PMID: 10373332 abstract
full text
Leonard JC, Toji LH, Bender PK, Beiswanger CM, Beck JC
Regional mapping panels for chromosomes 8, 13, 21, and 22.
Genomics 51(1):17-20, 1998.
PMID: 9693028 abstract
full text
Toji LH, Lenchitz TC, Kwiatkowski VA, Sarama JA, Mulivor RA
Validation of routine mycoplasma testing by PCR.
In Vitro Cell Dev Biol Anim 34(5):356-8, 1998.
PMID: 9639095 abstract
Leonard JC, Drwinga HL, Kim CH, Toji LH, Bender PK, Mulivor RA, Beck JC
Regional mapping panels for chromosomes 3, 4, 5, 11, 15, 17, 18, and X.
Genomics 46(3):530-4, 1997.
PMID: 9441767 abstract
full text
Drwinga HL, Toji LH, Kim CH, Greene AE, Mulivor RA
NIGMS human/rodent somatic cell hybrid mapping panels 1 and 2.
Genomics 16(2):311-4, 1993.
PMID: 8314568 abstract
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