 Donald Coppock, Ph.D. is Assistant Director of the Coriell Cell Repositories. In this role, he manages the National Institute of General Medical Sciences Human Genetic Cell Repository and the National Institute on Aging Cell Repository. The mission for these repositories is to provide to the scientific community high quality cell lines and DNA samples from individuals with a wide range of inherited conditions.
Among several other projects, Dr. Coppock is developing a bioinformatic integration of the information from the data from the Coriell Cell Repositories with the information from the Human Genome Project. This integration will allow the Repositories to become even more useful as a basis for understanding human genetic diseases, including cancer.
As the Director of the Oncology Research Lab at Winthrop University Hospital in Mineola, NY and Assistant Professor and SUNY Stony Brook in Stony Brook, NY, Dr. Coppock developed two programs in cancer research: investigating how the malignant melanoma cell differs from the normal melanocyte in the regulation of cell growth and cell death, and investigating the mechanism by which normal cells arrest growth and how this differs from tumorigenic cells.
Dr. Coppock received his Ph.D. in cell biology at the University of California, where he studied the mechanism of insulin stimulation of growth in normal and transformed cells. He was offered a postdoctoral fellowship at the Dana-Farber Cancer Institute and Harvard Medical School to study regulation of cellular growth in normal and tumor cell model systems. In this role, he demonstrated that the level of the mRNA of thymidine kinase, an enzyme induced during the cell cycle, is regulated by a critical mechanism which regulates cell growth. In a second postdoctoral fellowship at Brandeis University in Waltham, MA, Dr. Coppock investigated the mechanisms regulating the onset of DNA synthesis using a cell-free system of frog egg cell extracts.
Representative Publications
Thorpe C., Hoober K.L., Raje S., Glynn N.M., Burnside J., Turi G.K., and Coppock D.L.
Sulfhydryl Oxidases: Emerging Catalysts of Protein Disulfide Bond Formation in Eukaryotes
Arch. Biophys. Biochem. 420:1-12, 2002.
PMID: 12176051 abstract
Arita Y., Santiago-Schwarz, F. and Coppock, D.L.
Survival mechanisms induced by 12-O-tetradecanoyl phorbol 13-acetate in normal human melanocytes include inhibition of apoptosis and increased Bcl-2 expression.
Melanoma Res. 10:1-9, 2000.
PMID: 11095401 abstract
Coppock, D.L., Kopman, C., Gudas, J. and Cina-Poppe, D.A.
Regulation of the quiescence induced genes: Quiescin Q6, Decorin, and Ribosomal Protein S29.
BBRC 269:604-610, 2000.
PMID: 10708601 abstract
Hoober,K.L., Glynn,N.M., Burnside,J., Coppock, D.L. and Thorpe, C.
Homology between egg white sulfhydryl oxidase and quiescin Q6 defines a new class of flavin-linked sulfhydryl oxidases.
J. Biol. Chem. 274:31759-31762, 1999.
PMID: 10542195 abstract
Coppock, D.L., Cina-Poppe, D.A., and Gilleran, S.N.
The quiescin Q6 gene is the fusion of two ancient gene families: Thioredoxin and ERV1.
Genomics 54:460-468, 1998.
PMID: 9878249
abstract
Arita, Y. and Coppock, D.L.
TPA causes G2 arrest of Demel melanoma cells by blocking activation of p34cdc2 : a role for activated protein kinase C.
Exp. Cell Res. 242:381-390, 1998.
|
|
|
