 Christine M. Beiswanger, Ph.D. is an Associate Professor at Coriell Institute (CIMR) and Assistant Director of the Coriell Cell Repositories (CCR), the world's largest and most important collection of human cells, gathered and distributed for use by the entire international scientific community.
In this role, she manages the Cell Culture Laboratories and Cryogenic Facility at Coriell Institute. The cell culture laboratories are responsible for the collection, establishment, and distribution of cell cultures from individuals with a variety of human genetic disorders and chromosomal abnormalities. In addition to the lymphoblast, fibroblast and differentiated cell lines preserved in the Cryogenic Facility, the Cell Culture Laboratories also expand cell lines for the isolation of DNA and RNA for distribution to other scientific facilities. The Coriell Cryogenic Facility serves as the primary and remote cryogenic storage site for the National Institute of General Medical Sciences, National Institute of Aging, National Institute of Neurological Diseases and Stroke, National Science Foundation Integrated Primate Biomaterials and Information Resource, National Cancer Institute, and the American Diabetes Association and houses many other cell collections, both large and small.
Research efforts are ongoing in the cell culture laboratories to improve the quality and characterization of all cell lines banked at Coriell. The cell culture laboratories are investigating the role of antioxidants in promoting cell growth in culture and the growth of cells after prolonged cryogenic storage, the optimization of media and culture practices for many different human cell types and for non-human primates.
After receiving her Ph.D. in Neurophysiology at the State University of New York in Albany in the study of single-neuron circadian rhythms, Dr. Beiswanger received a National Institutes of Health Research Service Award which supported her postdoctoral training at the School of Biological Sciences at the University of Kentucky on the neural control of photoperiodic locomotory behavior in Limax (terrestrial slug). Further study of the basis of molluscan behavior was supported by a Grass Foundation Fellowship at the Marine Biological Laboratory in Woods Hole, Massachusetts. Dr. Beiswanger moved to the Department of Zoology at Arizona State University, where she was Assistant Professor engaged in research in the neural basis of behavior and in teaching neurophysiology and biological rhythms. After leaving ASU, she was Director of Quality Control at AgResearch, Inc. Chandler, AZ, an integrated pest management company involved in control of the pink bollworm in the California cotton agribusiness.
Dr. Beiswanger returned to basic research using cell culture models to study neural plasticity at the Worcester Foundation for Experimental Biology in Worcester, MA and the Neutoxicology Laboratories at Rutgers College of Pharmacy in Piscataway, NJ. She joined Coriell Institute in 1996 as Supervisor of the Cell Culture and Cryogenic Laboratories and became Assistant Director in 1997.
Representative Publications
Beck JC, Beiswanger CM, John EM, Satariano E, West D.
Successful transformation of cryopreserved lymphocytes: a resource for epidemiological studies. Cancer Epidemiol Biomarkers Prev. 10(5):551-4, 2001.
PMID: 11352867
abstract
Leonard, JC, Toji, LH, Bender PK, Beiswanger, CM, Beck, JC, Johnson, RT
Regional mapping panels for human chromosomes 1, 2, and 7.
Somatic Cell and Molecilar Genetics 25(4):247-251, 2001.
Leonard JC, Toji LH, Bender PK, Beiswanger CM, Beck JC, Johnson RT
Panel description. Regional mapping panels for chromosomes 6, 9, and 16.
Genomics 58(3):323-6, 1999.
PMID: 10373332 abstract
full text
Leonard JC, Toji LH, Bender PK, Beiswanger CM, Beck JC
Regional mapping panels for chromosomes 8, 13, 21, and 22.
Genomics 51(1):17-20, 1998.
PMID: 9693028 abstract
full text
Beiswanger CM, Diegmann MH, Novak RF, Philbert MA, Graessle TL, Reuhl KR, Lowndes HE.
Developmental changes in the cellular distribution of glutathione and glutathione S-transferases in the murine nervous system.
Neurotoxicology 16(3):425-40, 1995.
PMID: 8584275 abstract
full text
Beiswanger CM, Mandella RD, Graessle TR, Reuhl KR, Lowndes HE
Synergistic neurotoxic effects of styrene oxide and acrylamide: glutathione-independent necrosis of cerebellar granule cells.
Toxicol Appl Pharmacol 118(2):233-44, 1993.
PMID: 8442002 abstract
Beiswanger CM, Roscoe-Graessle TL, Zerbe N, Reuhl KR, Lowndes HE
3-Acetylpyridine-induced degeneration in the dorsal root ganglia: involvement of small diameter neurons and influence of axotomy.
Neuropathol Appl Neurobiol 19(2):164-72, 1993.
PMID: 8316336 abstract
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