Dr. Dorit Berlin is Principal Investigator for the Coriell Institute's National Institute of General Medical Sciences (NIGMS) Human Genetic Cell Repository, a large biobank of cell lines and nucleic acids focusing on inherited disorders. Her responsibilities include managing the day-to-day scientific operations of the biobank, recruiting new samples, identifying new directions for the biorepository, and interfacing with government project officers.
Established at Coriell in 1972, the NIGMS Human Genetic Cell Repository (http://ccr.coriell.org/Sections/Collections/NIGMS) has for the past 38 years been providing scientists around the world with highly characterized cell lines and high-quality DNA for use in biomedical research. Repository samples represent a variety of disease states, chromosomal abnormalities, apparently healthy individuals, and many distinct human populations.
Prior to arriving at Coriell, Dr. Berlin was a postdoctoral scholar at Stanford University, where she worked on scientific curation for the Pharmacogenomics Knowledge Base (PharmGKB: www.pharmgkb.org), synthesizing pharmacogenomic knowledge, generating database and website content, and participating in external collaborations. Dr. Berlin also founded and led an education project to create DNATwist (www.dnatwist.org), a web-based pharmacogenomics teaching module. She led the implementation of this material as an online exhibit for the Tech Museum of Innovation, now available at http://www.thetech.org/exhibits/online/ugenetics/ from the “Blushing from Alcohol” link.
Publications
Vascular endothelial growth factor pathway.
Maitland ML, Lou XJ, Ramirez J, Desai AA, Berlin DS, McLeod HL, Weichselbaum RR, Ratain MJ, Altman RB, Klein TE. Pharmacogenet Genomics 2010 Jan 29. [Epub ahead of print]
PMID: 20124951 No abstract available.
Antiestrogen pathway (aromatase inhibitor).
Desta Z, Nguyen A, Flockhart D, Skaar T, Fletcher R, Weinshilboum R, Berlin DS, Klein TE, Altman RB. Pharmacogenet Genomics. 2009 Jul;19(7):554-5.
PMID: 19512956 No abstract available.
Very important pharmacogene summary: sulfotransferase 1A1.
Hildebrandt M, Adjei A, Weinshilboum R, Johnson JA, Berlin DS, Klein TE, Altman RB.
Pharmacogenet Genomics. 2009 Jun;19(6):404-6. Review.
PMID: 19451861 No abstract available.
Clinically available pharmacogenomics tests.
Flockhart DA, Skaar T, Berlin DS, Klein TE, Nguyen AT.
Clin Pharmacol Ther. 2009 Jul;86(1):109-13. Epub 2009 Apr 15. Review.
PMID: 19369936 abstract
PharmGKB: understanding the effects of individual genetic variants.
Sangkuhl K, Berlin DS, Altman RB, Klein TE. Drug Metab Rev. 2008;40(4):539-51.
PMID: 18949600 abstract
Dosage compensation proteins targeted to X chromosomes by a determinant of hermaphrodite fate. Dawes HE, Berlin DS, Lapidus DM, Nusbaum C, Davis TL, Meyer BJ.
Science. 1999 Jun 11;284(5421):1800-4.
PMID: 10364546 abstract
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