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Press Release - June 02, 2008 Print E-mail

Huntington's disease biomaterials available through Coriell catalog (CHDI)


CHDI logo   CHDI logo

CAMDEN, NJ--To enable the discovery of therapeutics that will slow or prevent Huntington's disease (HD), research scientists require unobstructed access to biomaterials. Working together with the Coriell Institute for Medical Research, CHDI Foundation has established a secure, centralized repository to store and distribute quality-controlled and reliable research reagents. It is called the HD Community BioRepository.

"We built this repository with the idea that easy, centralized access to these bioresources will accelerate research efforts into treatments for this devastating disease," explained Dr. Douglas Macdonald, a director at CHDI Management and the project's leader. "Partnering with the Coriell Institute, a leader in the storage, quality control, and distribution of biological resources, means that these materials are trustworthy. With easier access to DNA plasmids, cell lines, and antibodies specific for Huntington's disease research, we hope to lower the barrier for entry and thus lure a greater number of scientists to the field to help us face the challenges posed by research and development for the disease."

Huntington's disease is a fatal, familial disease caused by a mutation in the huntingtin gene. The mutation causes brain cells to malfunction, resulting in cognitive and physical impairments that, over the course of the disease, isolate and constrain the individual. There is currently no way to stop or reverse the course of Huntington's disease.

The HD Community BioRepository (http://ccr.coriell.org/Sections/Collections/CHDI/) currently provides access to 53 huntingtin DNAs engineered in various laboratories, some working with CHDI. Many others are now being prepared. In the future, CHDI will also deposit antibodies with antigenic peptides, cell lines, and hybridomas when they become available.

"CHDI's commitment to providing laboratories with essential resources facilitated the design of our new IT system which supports the repositories and accelerates the online process for requesting materials," said Joe Mintzer, COO at Coriell. This system will likely serve as a prototype for Coriell's other collections. This innovation was important in streamlining access to CHDI and other Huntington's disease bioresources and reducing the cost of supporting the systems."

Researchers currently not collaborating with CHDI Foundation may request these Huntington's disease resources from the HD Community BioRepository through the website; CHDI collaborators should contact Mithra Mahmoudi at CHDI Management. Materials will be sent after completing a simple online MTA. Recipients are asked to cover the costs of shipping and handling.

Persons who are interested in making their HD bioresources available to the research community through the HD Community BioRepository are encouraged to contact Mithra Mahmoudi.

About CHDI Foundation, Inc.

CHDI Foundation is a non-profit organization supporting an international network of academic and industrial research laboratories pursuing novel ways to treat Huntington's disease with drugs. The organization's virtual pharma approach is designed to bring the right collaborators together to identify and address critical scientific issues and move drug candidates to clinical evaluation as quickly as possible.

About CHDI Management, Inc.

CHDI Management provides management services to CHDI Foundation from offices in New York, NY; Los Angeles, CA; and Princeton, NJ. CHDI Management has a staff of science and other professionals who manage a worldwide network of researchers working to find treatments for HD. Please contact Bonnie Lee La Madeleine at for more information about CHDI.

About Coriell Institute

The Coriell Institute for Medical Research is an internationally known, non-profit, biomedical research institution headquartered in Camden, NJ. Founded in 1953, the Institute conducts research on cancer, human genetic variation, mechanisms of cellular differentiation, and other genetic disorders. Coriell is the world's leading biobank resource for human cells and recently established a state of the art genotyping and microarray center. This new facility processes the genome profiles for the Coriell Personalized Medicine Collaborative™. Visit http://www.coriell.org for more information.

Contacts

For CHDI
Mithra Mahmoudi, MS
Biological Repositories Manager
CHDI Management, Inc.
email:
t: 310-342-5505

For Coriell
Lorraine H. Toji, Ph.D.
Principal Investigator
email:
t: 856-757-9719

For Coriell
Timothy Rhodes
Project Manager
email:
t: 856-966-5059

 
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